3-oxo-C12-aniline

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Names

[ CAS No. ]:
1186509-19-2

[ Name ]:
3-oxo-C12-aniline

[Synonym ]:
3-oxo-N-phenyl-Dodecanamide, LasR inhibitor, non-hydrolysable head group

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₇NO₂

[ Molecular Weight ]:
289.41

[ Storage condition ]:
−20°C

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Modulation of bacterial quorum sensing with synthetic ligands: systematic evaluation of N-acylated homoserine lactones in multiple species and new insights into their mechanisms of action.

J. Am. Chem. Soc. 129(44) , 13613-25, (2007)

Bacteria use a language of low molecular weight ligands to assess their population densities in a process called quorum sensing. This chemical signaling process plays a pivotal role both in the pathog...

Design, synthesis and biological evaluation of abiotic, non-lactone modulators of LuxR-type quorum sensing McInnis CE, and Blackwell HE

Bioorg. Med. Chem. 19 , 4812-4819, (2011)

Mutational Analysis of the Quorum-Sensing Receptor LasR Reveals Interactions that Govern Activation and Inhibition by Nonlactone Ligands. Gerdt JP, et al.

Chem. Biol. 21 , 1361-1369, (2014)

Pseudomonas aeruginosa autoinducer
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