3-oxo-C12-aniline

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Names

[ CAS No. ]:
1186509-19-2

[ Name ]:
3-oxo-C12-aniline

[Synonym ]:
3-oxo-N-phenyl-Dodecanamide, LasR inhibitor, non-hydrolysable head group

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₇NO₂

[ Molecular Weight ]:
289.41

[ Storage condition ]:
−20°C

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Modulation of bacterial quorum sensing with synthetic ligands: systematic evaluation of N-acylated homoserine lactones in multiple species and new insights into their mechanisms of action.

J. Am. Chem. Soc. 129(44) , 13613-25, (2007)

Bacteria use a language of low molecular weight ligands to assess their population densities in a process called quorum sensing. This chemical signaling process plays a pivotal role both in the pathog...

Design, synthesis and biological evaluation of abiotic, non-lactone modulators of LuxR-type quorum sensing McInnis CE, and Blackwell HE

Bioorg. Med. Chem. 19 , 4812-4819, (2011)

Mutational Analysis of the Quorum-Sensing Receptor LasR Reveals Interactions that Govern Activation and Inhibition by Nonlactone Ligands. Gerdt JP, et al.

Chem. Biol. 21 , 1361-1369, (2014)

Pseudomonas aeruginosa autoinducer
3-Oxo-N-phenylbutanamide
3-oxo-N-[5-(3-oxobutanoylamino)naphthalen-1-yl]butanamide
3-oxo-4-[(2-phosphonophenyl)hydrazinylidene]naphthalene-2-carboxylic acid
(-)-3-OXO-6-BETA-TRITYLOXYMETHYL-7-ALPHA-BENZOYL-OXY-2-OXABICYCLO[3.3.0!OCTANE
(3-Oxo-1-piperidinyl)acetic acid
5-[4-(5-Chloro-2-methylphenyl)piperazine-1-carbonyl]-2-methoxypyrimidine
N-[(2-ethoxyphenyl)methyl]-2-methoxypyrimidine-5-carboxamide
N-(3,4-dimethoxyphenethyl)-4-(6-((2-((4-(dimethylamino)phenyl)amino)-2-oxoethyl)thio)-8-oxo-[1,3]dioxolo[4,5-g]quinazolin-7(8H)-yl)butanamide
N-(benzo[d][1,3]dioxol-5-yl)-2-((7-(4-((3,4-dimethoxyphenethyl)amino)-4-oxobutyl)-8-oxo-7,8-dihydro-[1,3]dioxolo[4,5-g]quinazolin-6-yl)thio)butanamide
N-[(4-methoxyphenyl)methyl]-6-[6-({1-[(3-methoxypropyl)carbamoyl]propyl}sulfanyl)-8-oxo-2H,7H,8H-[1,3]dioxolo[4,5-g]quinazolin-7-yl]hexanamide
6-[6-[(1-{[(2-furylmethyl)amino]carbonyl}propyl)thio]-8-oxo[1,3]dioxolo[4,5-g]quinazolin-7(8H)-yl]-N-(4-methoxybenzyl)hexanamide
6-(6-{[(benzylcarbamoyl)methyl]sulfanyl}-8-oxo-2H,7H,8H-[1,3]dioxolo[4,5-g]quinazolin-7-yl)-N-[(4-methoxyphenyl)methyl]hexanamide
N-(4-methoxybenzyl)-6-(8-oxo-6-((2-oxo-2-(phenethylamino)ethyl)thio)-[1,3]dioxolo[4,5-g]quinazolin-7(8H)-yl)hexanamide
N-(4-methoxybenzyl)-6-(6-((2-((4-methoxyphenyl)amino)-2-oxoethyl)thio)-8-oxo-[1,3]dioxolo[4,5-g]quinazolin-7(8H)-yl)hexanamide
6-(6-((2-((2,4-dimethoxyphenyl)amino)-2-oxoethyl)thio)-8-oxo-[1,3]dioxolo[4,5-g]quinazolin-7(8H)-yl)-N-(4-methoxybenzyl)hexanamide

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