D-Mannitol,1,6-dimethanesulfonate

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Names

[ CAS No. ]:
1187-00-4

[ Name ]:
D-Mannitol,1,6-dimethanesulfonate

[Synonym ]:
O1,O6-Dimethansulfonyl-D-mannit
Mannogranol
D-Mannitol busulphan
D-Mannitol busulfan
O1,O6-bis-methanesulfonyl-D-mannitol
1,6-Bis-methansulfonyl-D-mannit
MANNITOL,1,6-DIMETHYLSULPHONATE,D
1,6-Di-O-methansulfonyl-D-mannitol
2511 C. B.
O1,O6-Bis-methansulfonyl-D-mannit
1,6-Dimethanesulfonate-D-mannitol
1,6-Bis-methansulfonyloxy-D-manno-hexan-2,3,4,5-tetraol
1,6-Dimesyl-D-mannitol
1,6-Di-O-methansulfonyl-D-mannit
1,6-Dimethanesulfonoxy-D-mannitol

Chemical & Physical Properties

[ Density]:
1.635g/cm3

[ Boiling Point ]:
721.3ºC at 760 mmHg

[ Melting Point ]:
134-136 °C

[ Molecular Formula ]:
C8H18O10S2

[ Molecular Weight ]:
338.35300

[ Flash Point ]:
390ºC

[ Exact Mass ]:
338.03400

[ PSA ]:
184.42000

[ Vapour Pressure ]:
5.01E-24mmHg at 25°C

[ Index of Refraction ]:
1.553

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OP2975000
CHEMICAL NAME :
Mannitol, 1,6-dimethanesulfonate, D-
CAS REGISTRY NUMBER :
1187-00-4
LAST UPDATED :
199707
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C8-H18-O10-S2
MOLECULAR WEIGHT :
338.38
WISWESSER LINE NOTATION :
WS1&O1YQYQYQYQ1OSW1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Blood - normocytic anemia Blood - thrombocytopenia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6 gm/kg
TOXIC EFFECTS :
Tumorigenic - protects against induction of experimental tumors
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2500 mg/kg
TOXIC EFFECTS :
Tumorigenic - protects against induction of experimental tumors
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
135 mg/kg
TOXIC EFFECTS :
Blood - leukopenia Blood - agranulocytosis Blood - other changes
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
135 mg/kg
TOXIC EFFECTS :
Blood - leukopenia Blood - agranulocytosis Blood - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1000 mg/kg/4W
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors
TYPE OF TEST :
Specific locus test
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST :
Sex chromosome loss and nondisjunction
TYPE OF TEST :
Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - rabbit Bone marrow
DOSE/DURATION :
1700 umol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 25,1705,1976

Safety Information

[ HS Code ]:
2905499000

Customs

[ HS Code ]: 2905499000

[ Summary ]:
2905499000 other polyhydric alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Related Compounds

  • D-Mannitol 1,6-bis(2-isocyano-3-methyl-2-butenoate)
  • D-Mannitol,1,6-bis-O-(triphenylmethyl)-, tetraacetate (9CI)
  • D-Mannitol,1,6-dibenzenesulfonate
  • D-Mannitol,1,6-bis[(2-chloroethyl)amino]-1,6-dideoxy-, dihydrochloride (9CI)
  • D-MANNITOL, 1,6-DIBENZOATE
  • [(2R,3R,4R,5R)-2,5-dihydroxy-3,4-dimethoxy-6-methylsulfonyloxyhexyl] methanesulfonate
  • N-[2-(2,3-dioxoquinoxalin-1-ium-1-yl)ethyl]-4-(1-methylindol-3-yl)butanamide
  • tert-Butyl 2-(furan-2-yl)pyrrolidine-1-carboxylate
  • N-(Methylsulfonyl)-L-phenylalanyl-L-alanylglycinamide
  • 2-Oxoalantolactone
  • N-(3,4-Dimethylisoxazol-5-yl)-4-((7-(trifluoromethyl)quinolin-4-yl)amino)benzenesulfonamide
  • 4-(4-Aminobutan-2-yl)phenol
  • 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine
  • tert-Butyl 4-amino-3-methylpiperidine-1-carboxylate 2-hydroxypropane-1,2,3-tricarboxylate
  • N-(6-Methoxy-4-methylquinolin-8-yl)acetamide
  • 3-(Piperidin-4-yl)oxazolidin-2-one 4-methylbenzenesulfonate
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