Carglumic Acid

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Names

[ CAS No. ]:
1188-38-1

[ Name ]:
Carglumic Acid

[Synonym ]:
(S)-2-Ureidopentanedioic acid
(2S)-2-(carbamoylamino)pentanedioic acid
N-Carbamyl-L-glutamic Acid
MFCD00047874

Chemical & Physical Properties

[ Density]:
1.499g/cm3

[ Boiling Point ]:
438.1ºC at 760 mmHg

[ Melting Point ]:
174°

[ Molecular Formula ]:
C6H10N2O5

[ Molecular Weight ]:
190.15400

[ Flash Point ]:
218.8ºC

[ Exact Mass ]:
190.05900

[ PSA ]:
129.72000

[ LogP ]:
0.06390

[ Vapour Pressure ]:
6.7E-09mmHg at 25°C

[ Index of Refraction ]:
1.544

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LZ9870000
CHEMICAL NAME :
L-Glutamic acid, N-(aminocarbonyl)-
CAS REGISTRY NUMBER :
1188-38-1
LAST UPDATED :
199209
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C6-H10-N2-O5
MOLECULAR WEIGHT :
190.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 24(4),32,1990

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36/37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
LZ9870000

Synthetic Route

Click to get detail synthetic route

Articles

Biochemical efficacy of N-carbamylglutamate in neonatal severe hyperammonaemia due to propionic acidaemia.

Eur. J. Pediatr. 169(1) , 133-4, (2010)

Pricing of orphan drugs.

Lancet 373(9662) , 462, (2009)

Effect of dietary arginine and N-carbamoylglutamate supplementation on reproduction and gene expression of eNOS, VEGFA and PlGF1 in placenta in late pregnancy of sows.

Anim. Reprod. Sci. 132(3-4) , 187-92, (2012)

The objectives of this study were to investigate the potential mechanisms of dietary arginine (Arg) and N-carbamoylglutamate (NCG) supplementation on reproductive performance of sows. Twenty-seven cro...


More Articles

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