1(2H)-Phthalazinone

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Names

[ CAS No. ]:
119-39-1

[ Name ]:
1(2H)-Phthalazinone

[Synonym ]:
phthalazinol
1(2H)-phthalazinone
2,3-Phthalazinone
1,2H-PHTHALAZONE
phthalazin-1(2H)-one
1-phthalazinone
MFCD00006892
1,2-Dihydro-1-oxophthalazine
PTLZ
1-oxophthalazine
phthalazin-1-one
Benzo[d]pyridazin-1(2H)one
EINECS 204-319-8
phthalazinone
Pthalazone
2H-phthalazin-1-one
PHTHALAZONE
Phthalazin-1-ol
1-phthalazinol
Phtalazin-1-ol
1(2H)-Phthalazinone

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
423.4±18.0 °C at 760 mmHg

[ Melting Point ]:
183-185 °C(lit.)

[ Molecular Formula ]:
C8H6N2O

[ Molecular Weight ]:
146.146

[ Flash Point ]:
209.9±21.2 °C

[ Exact Mass ]:
146.048019

[ PSA ]:
45.75000

[ LogP ]:
0.82

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.705

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TH9185000
CHEMICAL NAME :
1(2H)Phthalazinone
CAS REGISTRY NUMBER :
119-39-1
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C8-H6-N2-O
MOLECULAR WEIGHT :
146.16
WISWESSER LINE NOTATION :
T66 BVMNJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
370 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IHFCAY Industrial Hygiene Foundation of America, Chemical and Toxicological Series, Bulletin. (Pittsburgh, PA) 1947-69. Volume(issue)/page/year: 6,1,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00139

Safety Information

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36/37/38;R68

[ Safety Phrases ]:
S22-S24/25-S36/37/39-S26

[ WGK Germany ]:
3

[ RTECS ]:
TH9185000

[ HS Code ]:
29339990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Carboxybenzaldehyde
  • 2-(dibromomethyl)benzoic acid
  • Phthalazine
  • 2-(3-oxo-1H-2-benzofuran-1-yl)phthalazin-1-one
  • 2-Ketoglutaric acid
  • Hydralazine hydrochloride
  • Acetone
  • Isoindolin-1-one
  • 4-OXO-3,4-DIHYDROPHTHALAZINE-1-CARBOXYLIC ACID

DownStream

  • 2-[3-(4-chlorophenyl)-3-oxoprop-1-en-2-yl]phthalazin-1-one
  • Isoindoline
  • 1-Aminophthalazine
  • 1-Methoxyphthalazine
  • 1-CHLOROPHTHALAZINE
  • 1-Phenoxyphthalazine
  • 2-(4-bromobutyl)phthalazin-1-one
  • 4-Phenyl-2-hydrophthalazin-1-one
  • 1(2H)-Phthalazinethione
  • 2-(2-bromoethyl)phthalazin-1-one

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 1(2H)-Phthalazinone
  • 1(2H)-phthalazinone
  • 1(2H)-Phthalazinone,2-iodo
  • 1(2H)-Phthalazinone,2-ethyl
  • 1(2H)-Phthalazinone,7-nitro
  • 7-Fluoro-1(2H)-phthalazinone
  • N-((2-(thiophen-3-yl)pyridin-3-yl)methyl)benzo[d]thiazole-2-carboxamide
  • 3-(3-bromo-4-methoxyphenyl)-N-((2-(thiophen-3-yl)pyridin-3-yl)methyl)propanamide
  • 5-fluoro-2-methoxy-N-((2-(thiophen-3-yl)pyridin-3-yl)methyl)benzenesulfonamide
  • 2-(2,4-dichlorophenoxy)-N-((2-(thiophen-2-yl)pyridin-4-yl)methyl)acetamide
  • 3-(benzyloxy)-N-((2-(furan-2-yl)pyridin-4-yl)methyl)benzamide
  • N-((2-(furan-2-yl)pyridin-4-yl)methyl)-5-methyl-1-phenyl-1H-pyrazole-4-carboxamide
  • N-((2-(furan-2-yl)pyridin-4-yl)methyl)-6-(trifluoromethyl)nicotinamide
  • N-methyl-N-{[2-(morpholin-4-yl)phenyl]methyl}hydroxylamine
  • 4-(tert-butyl)-N-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)benzamide
  • 5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid hydrochloride
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