2,2'-Methylenebis(6-tert-butyl-4-methylphenol)

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Names

[ CAS No. ]:
119-47-1

[ Name ]:
2,2'-Methylenebis(6-tert-butyl-4-methylphenol)

[Synonym ]:
MFCD00043641
2-tert-Butyl-6-(2-hydroxy-3-tert-butyl-5-methyl-benzyl)-4-methyl-phenol
Cyanox 2246
2,2'-Methylenebis[4-methyl-6-(2-methyl-2-propanyl)phenol]
3,3'-Di-tert-butyl-2,2'-dihydroxy-5,5'-dimethyldiphenylmethane
2,2'-Methylenebis(6-tert-butyl-p-cresol)
Phenol, 2,2'-methylenebis[6-(1,1-dimethylethyl)-4-methyl-
EINECS 204-327-1
p-Cresol, 2,2'-methylenebis[6-tert-butyl-
2,2'-Methylene-bis-(4-methyl-6-tert-butyl-phenol)
6,6'-Methylenebis(2-(tert-butyl)-4-methylphenol)
2,2'-methylenebis(6-tert-butyl-4-methylphenol)
Bis(3-tert-butyl-2-hydroxy-5-methylphenyl)methane
bis-[2-hydroxy-5-methyl-3-tert-butylphenyl]-methane
1X1&1&R BQ E1 C1R BQ E1 CX1&1&1

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
428.6±40.0 °C at 760 mmHg

[ Melting Point ]:
123-127 °C(lit.)

[ Molecular Formula ]:
C23H32O2

[ Molecular Weight ]:
340.499

[ Flash Point ]:
181.2±21.9 °C

[ Exact Mass ]:
340.240234

[ PSA ]:
40.46000

[ LogP ]:
7.03

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.551

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
PA3500000
CHEMICAL NAME :
Methane, 2,2'-bis(6-t-butyl-p-cresyl)-
CAS REGISTRY NUMBER :
119-47-1
BEILSTEIN REFERENCE NO. :
2062676
LAST UPDATED :
199710
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C23-H32-O2
MOLECULAR WEIGHT :
340.55
WISWESSER LINE NOTATION :
1X1&1&R BQ C3R BQ CX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,240,1986 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 38(8),28,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
11 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 19,77,1994 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1623 mg/kg/1W-C
TOXIC EFFECTS :
Liver - other changes Blood - changes in other cell count (unspecified) Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 8,77,1981
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
25200 mg/kg/12W-C
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 19,77,1994
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
23096 mg/kg/78W-C
TOXIC EFFECTS :
Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 19,77,1994 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82995 No. of Facilities: 275 (estimated) No. of Industries: 6 No. of Occupations: 23 No. of Employees: 5131 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82995 No. of Facilities: 6941 (estimated) No. of Industries: 70 No. of Occupations: 72 No. of Employees: 150745 (estimated) No. of Female Employees: 36237 (estimated)

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H361f-H413

[ Precautionary Statements ]:
P281

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ RTECS ]:
PA3500000

[ HS Code ]:
29072900

Synthetic Route

Precursor & DownStream

Precursor

  • Formaldehyde
  • 2-tert-Butyl-4-methylphenol
  • 2,4-Di-t-butylphenol
  • dimethoxymethane
  • Sulfuric acid
  • 6-tert-butyl-2-(2'-methoxy-3'-tert-butyl-5'-methylbenzyl)-4-methylphenol
  • p-Cresol
  • Methyl tert-butyl ether

DownStream

  • 4,4'-dimethylmethylenediphenol
  • 2-tert-Butyl-4-methylphenol
  • 1,9-ditert-butyl-3,7-dimethyl-11-phenoxy-5H-benzo[d][1,3,2]benzodioxaphosphocine
  • 2,4-Xylenol, 6-tert-butyl-
  • Diethylamine
  • bis[3-tert-butyl-5-methyl-2-(5,5-dimethyl-1,3,2-dioxaphosphorinan-2-yloxy)phenyl]methane
  • 2-(1,1-dimethylethyl)-6-[[3-(1,1-dimethylethyl)-2-hydroxy-5-methylphenyl]methyl]-4-methylphenyl acrylate
  • 2-Methylacrylic acid 2-tert-butyl-6-[(3-tert-butyl-2-hydroxy-5-methylphenyl)methyl]-4-methylphenyl ester

Customs

[ HS Code ]: 29072900

Articles

Bis(2-hydroxy-3-tert-butyl-5-methyl-phenyl)-methane (bis-phenol) is a potent and selective inhibitor of the secretory pathway Ca²⁺ ATPase (SPCA1).

Biochem. Biophys. Res. Commun. 424(3) , 616-9, (2012)

The secretory pathway Ca(2+) ATPase (SPCA) provides the Golgi apparatus with a Ca(2+) supply essential for Ca(2+)-dependent enzymes involved in the post-translational modification of proteins in trans...

Effects of four bisphenolic antioxidants on lipid contents of rat liver.

Toxicol. Lett. 8(1-2) , 77-86, (1981)

Hepatic lipids were studied in Sprague-Dawley male rats given, 2,2'-methylenebis(4-ethyl-6-tert-butylphenol), 2,2'-methylenebis(4-methyl-6-tert-butylphenol), 4,4'-butylidenebis(3-methyl-6-tert-butylph...

Inhibition of the sarcoplasmic and endoplasmic calcium pump by bis(2-hydroxy-3-tert-butyl-5-methyl)methane, (bis-phenol).

Biochem. Soc. Trans. 21(2) , 106S, (1993)


More Articles


Related Compounds

  • 2,2'-methylenebis(6-tert-butyl-4-methylphenol) monoacetate
  • 2,2'-methylenebis(6-tert-butyl-4-methylphenol) monopropionate
  • 2,2'-methylenebis[6-tert-butyl-4-isopropylphenol]
  • 2,2'-Methylenebis(6-tert-butyl-4-ethylphenol)
  • 2,2'-methylenebis(6-tert-butyl-4-methoxycarbonylphenol)
  • 2,2'-methylenebis[6-tert-butyl-3,4-xylenol]
  • Anticancer agent 182
  • 2-(5-(2,4-difluorophenyl)isoxazol-3-yl)-N-propylacetamide
  • 2-(5-(2,4-difluorophenyl)isoxazol-3-yl)-N-(2-(dimethylamino)ethyl)acetamide
  • N-Hydroxysuccinimido iminobiotinate
  • (2S)-8,5'-dihydroxy-7,3',4'-trimethoxyflavan
  • 2-chloro-N-(6-chloro-3-oxo-4H-1,4-benzoxazin-7-yl)acetamide
  • 2-(benzo[d]isoxazol-3-yl)-N-(2-((4-((4-methoxyphenyl)amino)-6-methylpyrimidin-2-yl)amino)ethyl)acetamide
  • 4-(N,N-dimethylsulfamoyl)-N-(2-((4-((4-methoxyphenyl)amino)-6-methylpyrimidin-2-yl)amino)ethyl)benzamide
  • (4-ethoxy-1-(4-fluorophenyl)-1H-pyrazol-3-yl)(pyrrolidin-1-yl)methanone
  • ethyl 1-[4-ethoxy-1-(4-fluorophenyl)-1H-pyrazole-3-carbonyl]piperidine-4-carboxylate
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