N,N'-ethylenebis(N-butylmorpholine-4-carboxamide)

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Names

[ CAS No. ]:
119-48-2

[ Name ]:
N,N'-ethylenebis(N-butylmorpholine-4-carboxamide)

[Synonym ]:
dimorpholamine
Atmurin
EINECS 204-328-7
Prontodin
N,N'-dibutyl-N,N'-ethanediyl-bis-morpholine-4-carboxamide
N,N'-Dibutyl-N,N'-aethandiyl-bis-morpholin-4-carbamid
Theraleptique
Theraptique
1064 TH
Amipan T

Chemical & Physical Properties

[ Density]:
1.114g/cm3

[ Boiling Point ]:
571.3ºC at 760mmHg

[ Molecular Formula ]:
C20H38N4O4

[ Molecular Weight ]:
398.54000

[ Flash Point ]:
299.3ºC

[ Exact Mass ]:
398.28900

[ PSA ]:
65.56000

[ LogP ]:
1.97080

[ Vapour Pressure ]:
4.63E-13mmHg at 25°C

[ Index of Refraction ]:
1.516

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QD9800000
CHEMICAL NAME :
4-Morpholinecarboxamide, N,N'-ethylenebis(N-butyl-
CAS REGISTRY NUMBER :
119-48-2
BEILSTEIN REFERENCE NO. :
0052277
LAST UPDATED :
199612
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C20-H38-N4-O4
MOLECULAR WEIGHT :
398.62
WISWESSER LINE NOTATION :
T6N DOTJ AVN4&2N4&V- AT6N DOTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
270 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,347,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
190 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,347,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
24 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,347,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
122 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,347,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
380 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - other changes
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 163,133,1966
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
80 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 163,133,1966
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
104 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 163,133,1966
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
42200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,347,1982

Safety Information

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • [[N,N'-ethylenebis[N-(carboxymethyl)glycinato]](4-)-N,N',O,O',ON,ON']cobaltate(2-)
  • N,N'-Ethylenebis(N-butyl-1-piperidinecarboxamide)
  • N,N'-ethylenebis[N-(carboxymethyl)glycine], compound with N,N-triethylamine and 2,2',2''-nitrilotris[ethanol]
  • N,N'-ethylenebis[N-(carboxymethyl)glycine], compound with 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:2)
  • calcium [[N,N'-ethylenebis[N-(carboxymethyl)glycinato]](4-)-N,N',O,O',ON,ON']cuprate(2-)
  • dipotassium [[N,N'-ethylenebis[N-(carboxymethyl)glycinato]](4-)-N,N',O,O']palladate(2-)
  • 2-(Methoxymethyl)-2-(propan-2-yl)oxirane
  • Propanoic acid, 3-[[(4-fluorophenyl)methyl](2-methoxyethyl)amino]-2-methyl-
  • (4-(2-((4-Methoxybenzyl)oxy)propan-2-yl)phenyl)magnesium bromide
  • 3-(1-methyl-1H-pyrazol-5-yl)butan-1-amine
  • 3-(2-Fluoro-5-methylphenyl)-3-methylbutan-1-amine
  • 3-Methyl-3-(4-methylcyclohexyl)butan-1-amine
  • 6-Methyl-3-nitro-2(1H)-pyridinethione
  • 2-Methyl-2-(2-methylquinolin-6-yl)propanoic acid
  • N-(4-cyanotetrahydropyran-4-yl)-4-(3,3,3-trifluoropropyl)benzamide
  • 4-(4-Cyano-1H-pyrazol-1-yl)benzoic acid
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