Isoquinoline

Suppliers

Names

[ CAS No. ]:
119-65-3

[ Name ]:
Isoquinoline

[Synonym ]:
ISOCHINOLIN
ISOQUINOLIN
Isochinoline
EINECS 204-341-8
ISOQINOLINE
Isoquinoline
LEUCOLINE
FEMA 2978
2-BENZAZINE
iso-quinoline
MFCD00006898
isoqionoline
2-Benzanine
Benzopyridine
Fasudil Impurity 14

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
243.2±0.0 °C at 760 mmHg

[ Melting Point ]:
26-28 °C(lit.)

[ Molecular Formula ]:
C9H7N

[ Molecular Weight ]:
129.159

[ Flash Point ]:
107.2±0.0 °C

[ Exact Mass ]:
129.057846

[ PSA ]:
12.89000

[ LogP ]:
1.96

[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.642

[ Water Solubility ]:
practically insoluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NW6825000
CHEMICAL NAME :
Isoquinoline
CAS REGISTRY NUMBER :
119-65-3
LAST UPDATED :
199806
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C9-H7-N
MOLECULAR WEIGHT :
129.17
WISWESSER LINE NOTATION :
T66 CNJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,848,1986 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
360 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 4,119,1951
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
590 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 4,119,1951
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948 Volume(issue)/page/year: -,695,1948
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948 Volume(issue)/page/year: -,695,1948 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T0820 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 28314 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T0820 No. of Facilities: 432 (estimated) No. of Industries: 8 No. of Occupations: 11 No. of Employees: 2319 (estimated) No. of Female Employees: 316 (estimated)

Safety Information

[ Hazard Codes ]:
T:Toxic

[ Risk Phrases ]:
R22;R24;R38

[ Safety Phrases ]:
S36/37-S45-S36/37/39

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
2

[ RTECS ]:
NW6825000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1,2,3,4-Tetrahydroisoquinoline
  • Isoquinoline N-oxide
  • 1-Isoquinolinecarboxylic acid
  • 4-Bromoisoquinoline
  • Phenylboronic acid
  • 2-[(TRIMETHYLSILYL)ETHYNYL]BENZALDEHYDE
  • o-Phthalaldehyde
  • Acetylene

DownStream

  • 4-naphthalen-2-ylpyridine
  • 1-methyl-2-(1-methylbenzoimidazol-2-yl)benzoimidazole
  • 1-methyl-2-(1-methyl-3-benzoyl-1,2-dihydro-2-benzimidazolyl)benzimidazole
  • [1-(1-methylbenzimidazol-2-yl)-1H-isoquinolin-2-yl]-phenylmethanone
  • Benzil
  • (1-methyl-1H-benzoimidazol-2-yl)-phenyl-methanone
  • 4-Isoquinolinecarbonitrile
  • 8-Chloroisoquinoline
  • 3-Bromoisoquinoline

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • isoquinoline
  • Isoquinoline-d
  • isoquinoline HCl
  • isoquinoline red
  • iodoisoquinoline
  • isoquinolinethiol
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • 6-(5-Ethyl-2-methoxyphenyl)-4-trifluoromethyl-2-hydroxypyridine-3-carbonitrile
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • JWH-018 2'-Naphthyl-N-(1,2-dimethylpropyl)
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine