4,6-dichloropyrimidine

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Names

[ CAS No. ]:
1193-21-1

[ Name ]:
4,6-dichloropyrimidine

[Synonym ]:
4,6-dichlorpyrimidin
Pyrimidine, 4,6-dichloro-
EINECS 214-770-2
4,6-Dichloro-1,3-diazine
Pyrimidine,4,6-dichloro
MFCD00006109
4,6-dichloropyrimidine
4,6-dichloro-pyrimidine
4,6-dichloropyrimidne

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
176.0±0.0 °C at 760 mmHg

[ Melting Point ]:
65-67 °C(lit.)

[ Molecular Formula ]:
C4H2Cl2N2

[ Molecular Weight ]:
148.978

[ Flash Point ]:
105.1±7.4 °C

[ Exact Mass ]:
147.959503

[ PSA ]:
25.78000

[ LogP ]:
1.29

[ Vapour Pressure ]:
1.5±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.559

[ Storage condition ]:
-20°C

MSDS

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C: Corrosive;

[ Risk Phrases ]:
R20/21/22;R34

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 3263 8/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
II

[ Hazard Class ]:
8

[ HS Code ]:
2942000000

Synthetic Route

Precursor & DownStream

Precursor

  • 4,6-Dihydroxypyrimidine
  • phosgene
  • (Z)-Methanimidic acid
  • Acetonitrile
  • 5-Ethyl-2-methylpyridine
  • Acetamide
  • formamide,hydrochloride
  • acetamide,hydrochloride
  • 4-Chloro-6-(methylthio)pyrimidine
  • Ethyl cyanoformate

DownStream

  • 2-(6-Chloro-pyrimidin-4-yloxy)-quinoxaline
  • 2-(6-Chloropyrimidin-4-yl)-2H-[1,2,4]triazol-3-ylamine
  • 4-Chloro-6-hydrazinopyrimidine
  • 4,6-Dimethoxypyrimidine
  • fenclorim
  • 6-Chloro-N,N-dimethylpyrimidin-4-amine
  • 4-(6-Hydrazino-4-pyrimidinyl)Morpholine
  • 6-Chlorpyrimidin-4-ol
  • 4-CHLORO-6-PIPERIDINO-5-PYRIMIDINECARBALDEHYDE
  • 4-Chloro-6-(methylthio)pyrimidine

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Synthesis and highly selective bromination of Azacalix[4]pyrimidine macrocycles.

J. Org. Chem. 75(3) , 741-7, (2010)

A number of N-substituted azacalix[4]pyrimidines were synthesized by two methods. While straightforward condensation reaction between 4,6-dichloropyrimidine and 4,6-bis(alkylamino)pyrimidines gave ide...

Design, synthesis, and evaluation of novel biarylpyrimidines: a new class of ligand for unusual nucleic acid structures.

J. Med. Chem. 49 , 5187, (2006)

Biarylpyrimidines are characterized as selective ligands for higher-order nucleic acid structures. A concise and efficient synthesis has been devised incorporating Suzuki biaryl cross-coupling of diha...

Tetrahedron 62 , 10055, (2006)


More Articles


Related Compounds

  • 5-Amino-4,6-dichloropyrimidine
  • 2-BUTYL-4,6-DICHLOROPYRIMIDINE
  • 5-nitro-4,6-dichloropyrimidine
  • 2-Bromo-4,6-dichloropyrimidine
  • 5-ethyl-4,6-dichloropyrimidine
  • 5-Bromo-4,6-dichloropyrimidine