Cyclic ADP-​ribose

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Names

[ CAS No. ]:
119340-53-3

[ Name ]:
Cyclic ADP-​ribose

[Synonym ]:
cyclic ADP-D-ribose
Enzyme-activated NAD
adenosine 5'-cyclic-diphosphoribose
cyclic adenosine 5'-diphosphoribose
cADP-Ribose
Cyclic Adenosine Diphosphate Ribose
E-NAD
cADPR
Cyclic ADPR
cyclic adenosine 5'-diphosphate ribose
MFCD00214262

Chemical & Physical Properties

[ Density]:
2.57 g/cm3

[ Boiling Point ]:
934.8ºC at 760 mmHg

[ Molecular Formula ]:
C15H21N5O13P2

[ Molecular Weight ]:
541.30000

[ Flash Point ]:
519.1ºC

[ Exact Mass ]:
541.06100

[ PSA ]:
276.92000

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.959

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • NAD+
  • α-Nicotinamide adenine dinucleotide
  • β-NADP+

DownStream

Articles

Cyclic ADP-ribose requires CD38 to regulate the release of ATP in visceral smooth muscle.

FEBS J. 278 , 3095-3108, (2011)

It is well established that the intracellular second messenger cADP-ribose (cADPR) activates Ca(2+) release from the sarcoplasmic reticulum through ryanodine receptors. CD38 is a multifunctional enzym...

β-Adrenergic receptor signaling increases NAADP and cADPR levels in the heart.

Biochem. Biophys. Res. Commun. 427(2) , 326-9, (2012)

Evidence suggests that β-Adrenergic receptor signaling increases heart rate and force through not just cyclic AMP but also the Ca(2+)-releasing second messengers NAADP (nicotinic acid adenine dinucleo...

Pyridine nucleotide metabolites and calcium release from intracellular stores.

Adv. Exp. Med. Biol. 740 , 305-23, (2012)

Ca(2+) signals are probably the most common intracellular signaling elements, controlling an extensive range of responses in virtually all cells. Many cellular stimuli, often acting at cell surface re...


More Articles

Related Compounds

  • INOSINE-3',5'-CYCLIC PHOSPHATE
  • β-1'-O-methyl ADP ribose
  • 2'/3'-O-Acetyl ADP Ribose(A Mixture of 2'/3'-O-Acetyl ADP Ribose)
  • [(3R,4S,5R)-5-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-phosphonooxyphosphoryl]oxymethyl]-3,4-dihydroxyoxolan-2-yl] (2R)-2-amino-3-sulfanylpropanoate
  • [[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] (3,4,5-trihydroxyoxolan-2-yl)methyl hydrogen phosphate
  • Cyclic inosine diphosphate-ribose
  • N-(4-chlorophenyl)-N-[(3-fluorophenyl)methyl]-3-methyl-[1,2,4]triazolo[4,3-a]pyridine-8-sulfonamide
  • N-(4-chlorophenyl)-N-[(4-fluorophenyl)methyl]-3-methyl-[1,2,4]triazolo[4,3-a]pyridine-8-sulfonamide
  • 3-(3-Bromophenyl)-5-{[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]methyl}-1,2,4-oxadiazole
  • 3-(4-Bromophenyl)-5-{[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]methyl}-1,2,4-oxadiazole
  • N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-((5-(3-phenyl-1,2,4-oxadiazol-5-yl)pyridin-2-yl)thio)acetamide
  • N-(3-Methylcyclohexyl)-4-(trifluoromethyl)benzenamine
  • 6-(azepan-1-ylsulfonyl)-2-phenethyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
  • N-(2-methoxy-5-methylphenyl)-2-((5-(3-phenyl-1,2,4-oxadiazol-5-yl)pyridin-2-yl)thio)acetamide
  • N-(4-fluorophenyl)-2-((5-(3-phenyl-1,2,4-oxadiazol-5-yl)pyridin-2-yl)thio)acetamide
  • N-(1-cyclopropylethyl)oxan-4-amine
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