2,6-Dichlorobenzonitrile

Suppliers

Names

[ Name ]:
2,6-Dichlorobenzonitrile

[Synonym ]:
2,6-DICHLOROBENZNITRILE
2,6-Dichlor-benzoesaeure-aethylester
2,6-Dichlorobenzonitrile,Dichlobenil
Casaron
Dichlobenil
EINECS 214-787-5
2,6-Dichlorobenzonitrile
Casoron G
Ethyl-2,6-dichlorbenzoat
Niagara 5996
2,6-DICHLORO BENZONITRILE
2,5-DICHLORO-3,4,6-TRIFLUOROBENZENETHIOL
2,6-Dichlorocyanobenzene
2,6-Dichlorophenyl cyanide
2,6-dichloro-benzonitrile
NCR BG FG
2,6-dichloro-benzoic acid ethyl ester
MFCD00001781
Benzonitrile, 2,6-dichloro-

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
279.2±20.0 °C at 760 mmHg

[ Melting Point ]:
143-146 °C(lit.)

[ Molecular Formula ]:
C₇H₃Cl₂N

[ Molecular Weight ]:
172.011

[ Flash Point ]:
126.8±16.0 °C

[ Exact Mass ]:
170.964249

[ PSA ]:
23.79000

[ LogP ]:
2.79

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.584

[ Storage condition ]:
0-6°C

[ Water Solubility ]:
25 mg/L (25 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DI3500000

CHEMICAL NAME :: Benzonitrile, 2,6-dichloro-

CAS REGISTRY NUMBER :: 1194-65-6

BEILSTEIN REFERENCE NO. :: 1909167

LAST UPDATED :: 199801

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C7-H3-Cl2-N

MOLECULAR WEIGHT :: 172.01

WISWESSER LINE NOTATION :: NCR BG FG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2710 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 10,97,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971 Volume(issue)/page/year: -,145,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2056 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969 Volume(issue)/page/year: 5,73,1976

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >200 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - deviated nasal septum Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Biochemical - Metabolism (Intermediary) - lipids including transport

REFERENCE :: NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979- Volume(issue)/page/year: 15,287,1994

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 360 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 41,41,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 270 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Liver - other changes

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 6,261,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada) Volume(issue)/page/year: 6,177,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 681 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS) Volume(issue)/page/year: -,337,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971 Volume(issue)/page/year: -,144,1971 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg/5D-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - deviated nasal septum Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Biochemical - Metabolism (Intermediary) - lipids including transport

REFERENCE :: NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979- Volume(issue)/page/year: 15,287,1994 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 260 ug/kg/39D-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

REFERENCE :: AAATAP Annali dell'Accademia di Agricoltura di Torino. (Accademia de Agricoltura di Torino, Via Andrea Doria 10, 10123 Turin, Italy) 1870- Volume(issue)/page/year: 122,107,1979

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 260 ug/kg/39D-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Tumorigenic - tumors at site of application

REFERENCE :: AAATAP Annali dell'Accademia di Agricoltura di Torino. (Accademia de Agricoltura di Torino, Via Andrea Doria 10, 10123 Turin, Italy) 1870- Volume(issue)/page/year: 122,107,1979 *** REVIEWS *** TOXICOLOGY REVIEW DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 24030 No. of Facilities: 40 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 200 (estimated)

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H312-H411

[ Precautionary Statements ]:
P273-P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R21;R51/53

[ Safety Phrases ]:
S36/37-S61

[ RIDADR ]:
UN 3077 9/PG 3

[ WGK Germany ]:
2

[ RTECS ]:
DI3500000

[ Packaging Group ]:
III

[ Hazard Class ]:
9

[ HS Code ]:
2926909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2,6-Dichlorotoluene
2,6-Dichlorobenzaldoxime
2-Bromo-1,4-dichlorobenzene
2,6-Dichlorobenzaldehyde
(E)-2,6-dichlorobenzaldoxime
N-Methylpyrrolidone
2-chloro-6-nitrobenzonitrile
Ethane, 1,1-dichloro-
zinc,dicyanide
1,3-Dichloro-2-iodobenzene

DownStream

1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin
Octachlorooxanthrene
5-(2,6-dichlorophenyl)-1h-tetrazole
2,6-bis(2,2,2-trifluoroethoxy)benzonitrile
6-Fluoroanthranilic acid
2-Bromo-1-(2,6-dichlorophenyl)ethanone
Methyl 2-amino-6-fluorobenzoate
2,6-Difluorobenzonitrile
2-Chloro-6-fluorobenzonitrile
BAM

Customs

[ HS Code ]: 2926909090

[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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2,6-dichlorobenzonitrile
2,6-dichlorobenzonitrile
2,6-Dichlorobenzonitrile
2,6-dichlorobenzonitrile oxide
4-Amino-2,6-dichlorobenzonitrile
3-Bromo-2,6-dichlorobenzonitrile
Ethyl 4-ethoxy-3-fluoro-2-(methylthio)benzoate
1-Bromo-3-fluoro-2-iodo-4-(methoxymethoxy)benzene
{[2-(Ethanesulfonyl)thiophen-3-yl]methyl}(propyl)amine
(3-Iodo-5-(trifluoromethoxy)phenyl)(methyl)sulfane
1-{1-[(Propan-2-yloxy)methyl]cyclopropyl}ethan-1-ol
2-(3-Bromo-2-fluorophenyl)ethane-1-sulfonyl fluoride
5-(2-Fluoro-6-(trifluoromethyl)phenyl)thiazol-2-amine
5-(4-Bromo-3,5-dimethylphenyl)thiazol-2-amine
3-(2-Aminobutan-2-yl)-8-azabicyclo[3.2.1]octan-3-ol
1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 3-(pyridin-2-yl)propanoate

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