Topotecan hydrochloride

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Names

[ CAS No. ]:
119413-54-6

[ Name ]:
Topotecan hydrochloride

[Synonym ]:
Topotecan hydrochloride
MFCD00866235
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, (4S)-
9-[(Dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin
(S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]-quinoline-3,14(4H,12H)-dione
Topotecan
(4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Topotecan (Hydrochloride)

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
782.9±60.0 °C at 760 mmHg

[ Melting Point ]:
213-218ºC

[ Molecular Formula ]:
C23H24ClN3O5

[ Molecular Weight ]:
421.446

[ Flash Point ]:
427.3±32.9 °C

[ Exact Mass ]:
421.163757

[ PSA ]:
104.89000

[ LogP ]:
1.08

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.734

[ Storage condition ]:
Refrigerator

Safety Information

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
R25

[ Safety Phrases ]:
26-36/37/39-45

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Dichloromethane
  • (S)-10-Hydroxycamptothecin
  • Dimethylamine
  • Dibromomethane
  • Diiodomethane
  • Eschenmoser's reagent
  • (S)-10-((Dimethylamino)methyl)-4-ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl acetate
  • Topotecan hydrochloride hydrate
  • Formaldehyde

DownStream

Customs

[ HS Code ]: 2942000000

Related Compounds

  • .topotecan hydrochloride
  • Topotecan hydrochloride hydrate
  • Topotecan hydrochloride hydrate
  • Tyrocidine, hydrochloride
  • Triprolidine hydrochloride
  • Minoxidil hydrochloride