Citiolone

Suppliers

Names

[ Name ]:
Citiolone

[Synonym ]:
EINECS 214-793-8
3-Acetamidotetrahydro-2-thiophenone
N-Acetyl-DL-homocystein thiolactone
MFCD00005480
N-(2-oxothiolan-3-yl)acetamide
2-Acetamido-4-mercaptobutyric Acid γ-Thiolactone
DL-N-Acetylhomocysteine thiolactone
Citiolone

Chemical & Physical Properties

[ Density]:
1.263 g/cm3

[ Boiling Point ]:
427.265ºC at 760 mmHg

[ Melting Point ]:
109-111ºC

[ Molecular Formula ]:
C₆H₉NO₂S

[ Molecular Weight ]:
159.20600

[ Flash Point ]:
212.202ºC

[ Exact Mass ]:
159.03500

[ PSA ]:
71.47000

[ LogP ]:
0.54550

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC8680000

CHEMICAL NAME :: Acetamide, N-(tetrahydro-2-oxo-3-thienyl)-

CAS REGISTRY NUMBER :: 1195-16-0

BEILSTEIN REFERENCE NO. :: 0004338

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C6-H9-N-O2-S

MOLECULAR WEIGHT :: 159.22

WISWESSER LINE NOTATION :: T5SVTJ CMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1950 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,362,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,72,1958 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6028 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 2440 (estimated) No. of Female Employees: 1459 (estimated)

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T,Xi

[ Risk Phrases ]:
R25

[ Safety Phrases ]:
22-24/25-45-36-26

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
AC8680000

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Silver acetate
3-Aminodihydro-2(3H)-thiophenone hydrochloride
Acetyl chloride

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Interleukin-1 beta increases the activity of superoxide dismutase in rat pancreatic islets.

Endocrinology 130(5) , 2851-7, (1992)

The suppressive effects of interleukin-1 beta (IL-1 beta) on the function of pancreatic islets may be related to induction of gene transcription and protein synthesis. Presently, the effects of human ...

Inability of thiol compounds to restore CNS arylsulfatases inhibited by methyl mercury.

Pharmacol. Toxicol. 69(1) , 71-4, (1991)

Arylsulfatase A and B activities have been analysed in different areas of the CNS (olfactory bulbs, cerebral hemispheres, cerebellum, medulla oblongata and spinal cord) during methyl mercuric chloride...

Recurrent fixed drug eruption caused by citiolone.

J. Investig. Allergol. Clin. Immunol. 7(3) , 193-4, (1997)

Citiolone (N-acetylhomocysteinethiolactone) is a thiolic-derived medication frequently used in Spain and in other countries as a mucolytic agent for the treatment of certain hepatic disorders. Mucolyt...

Citiolone
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