Dabrafenib

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Names

[ CAS No. ]:
1195765-45-7

[ Name ]:
Dabrafenib

[Synonym ]:
Benzenesulfonamide, N-[3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-
UNII-QGP4HA4G1B
Tafinlar
Dabrafenib
N-{3-[5-(2-aminopyrimidin-4-yl)-2-(1,1-dimethylethyl)thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide
N-{3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzene sulfonamide
N-[3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide
N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(2-methyl-2-propanyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide
Dabrafenib (USAN)
Dabrafenib [USAN:INN]
N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide
GSK2118436

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
653.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H20F3N5O2S2

[ Molecular Weight ]:
519.562

[ Flash Point ]:
349.2±34.3 °C

[ Exact Mass ]:
519.101074

[ PSA ]:
148.21000

[ LogP ]:
3.54

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.626

[ Storage condition ]:
-20°C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1,1-diethylethyl)-1,3-thiazol-4-yl]-2-fluoraphenyl}-2,6-difluorobenzenesulfonamide
  • Methyl 3-amino-2-fluorobenzoate
  • Methyl 3-{[(2,6-difluoropheyl)sulfonyl]amino}-2-fluorabenzoate
  • methyl 3-(tert-butoxycarbonylamino)-2-fluorobenzoate
  • Methyl 3-bromo-2-fluorobenzoate
  • 3-Bromo-2-fluorobenzoic acid
  • 2,6-Difluorobenzenesulfonyl chloride

DownStream

  • Dabrafenib Mesylate

Related Compounds

  • Dabrafenib-d9
  • Hydroxy dabrafenib
  • Dabrafenib Mesylate
  • Desmethyl dabrafenib
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • Benzyl (4-methoxyphenyl)(methyl)carbamate
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • Methyl 2,3-difluoro-6-nitrobenzoate
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • 1-{3-[(Oxolan-3-yl)methoxy]azetidin-1-yl}-3,3-diphenylpropan-1-one