Dabrafenib Mesylate

Suppliers

Names

[ CAS No. ]:
1195768-06-9

[ Name ]:
Dabrafenib Mesylate

[Synonym ]:
Benzenesulfonamide, N-[3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-, methanesulfonate (1:1)
N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide,methanesulfonic acid
Tafinlar
N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(2-methyl-2-propanyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide methanesulfonate (1:1)
N-[3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide methanesulfonate (1:1)
UNII-B6DC89I63E
N-{3-[5-(2-aminopyrimidin-4-yl)-2-(1,1-dimethylethyl)thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide monomethanesulfonate
dabrafenib mesylate
GSK-2118436B
Dabrafenib (Mesylate)

Chemical & Physical Properties

[ Molecular Formula ]:
C24H24F3N5O5S3

[ Molecular Weight ]:
615.668

[ Exact Mass ]:
615.089172

[ PSA ]:
210.96000

[ LogP ]:
7.03360

[ Storage condition ]:
2-8℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Methanesulfonic acid
  • Dabrafenib
  • 2,6-Difluorobenzenesulfonyl chloride
  • Methyl 3-amino-2-fluorobenzoate
  • Methyl 3-{[(2,6-difluoropheyl)sulfonyl]amino}-2-fluorabenzoate
  • N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1,1-diethylethyl)-1,3-thiazol-4-yl]-2-fluoraphenyl}-2,6-difluorobenzenesulfonamide

DownStream

Related Compounds

  • Dabrafenib-d9
  • Dabrafenib
  • BPR1R024 mesylate
  • Tropisetron mesylate
  • TVP1022 (mesylate)
  • Alatrofloxacin Mesylate
  • 2-({1-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pent-4-enoyl]-3-methylazetidin-3-yl}oxy)acetic acid
  • 2-{1-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylpentanoyl]piperidin-3-yl}acetic acid
  • 2-{1-[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3,3-dimethylbutanamido]cyclopentyl}acetic acid
  • 2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-methoxybutanamido]cyclohexane-1-carboxylic acid
  • 4-{[1-(5-chlorothiophen-2-yl)ethyl]carbamoyl}-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoic acid
  • 2-{4-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylbutanoyl]-1,4-diazepan-1-yl}acetic acid
  • 2-{1-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pentanamido]cyclobutyl}acetic acid
  • 2-[N-(butan-2-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pent-4-ynamido]acetic acid
  • 4-[(cyclopentyloxy)carbamoyl]-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoic acid
  • (4R)-3-[6-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanoyl]-1,3-thiazolidine-4-carboxylic acid
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