Methyl 3-{[(2,6-difluoropheyl)sulfonyl]amino}-2-fluorabenzoate

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Names

[ CAS No. ]:
1195768-19-4

[ Name ]:
Methyl 3-{[(2,6-difluoropheyl)sulfonyl]amino}-2-fluorabenzoate

[Synonym ]:
Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate
Methyl 3-{[(2,6-difluorophenyl)sulfonyl]amino}-2-fluorobenzoate
SCHEMBL1127264
Benzoic acid, 3-[[(2,6-difluorophenyl)sulfonyl]amino]-2-fluoro-, methyl ester
Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate
COSCWKICERLCEK-UHFFFAOYSA-N

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
445.4±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C14H10F3NO4S

[ Molecular Weight ]:
345.294

[ Flash Point ]:
223.2±31.5 °C

[ Exact Mass ]:
345.028259

[ PSA ]:
80.85000

[ LogP ]:
2.23

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.572

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • methyl 3-(tert-butoxycarbonylamino)-2-fluorobenzoate

DownStream

  • Dabrafenib
  • Dabrafenib Mesylate
  • N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1,1-diethylethyl)-1,3-thiazol-4-yl]-2-fluoraphenyl}-2,6-difluorobenzenesulfonamide

Related Compounds

  • 1-benzyl-3-(benzyloxy)-N-(2,4-difluorophenyl)-1H-pyrazole-4-carboxamide
  • 1-benzyl-3-(benzyloxy)-N-(2,5-difluorophenyl)-1H-pyrazole-4-carboxamide
  • 8-(3-chlorophenyl)-3-(2-ethoxyethyl)-1,7-dimethyl-1H,2H,3H,4H,8H-imidazo[1,2-g]purine-2,4-dione
  • 8-(2,5-dimethoxyphenyl)-3-(3-hydroxypropyl)-1,7-dimethyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione
  • ethyl 2-(1,7-dimethyl-2,4-dioxo-8-(m-tolyl)-1H-imidazo[2,1-f]purin-3(2H,4H,8H)-yl)acetate
  • Methyl 2-[6-(2,5-dimethoxyphenyl)-4,7-dimethyl-1,3-dioxopurino[7,8-a]imidazol-2-yl]propanoate
  • 2-(8-(3-chloro-4-methylphenyl)-1-methyl-2,4-dioxo-7-phenyl-1H-imidazo[2,1-f]purin-3(2H,4H,8H)-yl)acetamide
  • Ethyl 2-(1,7-dimethyl-2,4-dioxo-3-pentyl-1,3,5-trihydro-4-imidazolino[1,2-h]pu rin-8-yl)acetate
  • 1-benzyl-3-(benzyloxy)-N-(4,5-dihydrothiazol-2-yl)-1H-pyrazole-4-carboxamide
  • ethyl 2-(2-(1-benzyl-3-(benzyloxy)-1H-pyrazole-4-carboxamido)thiazol-4-yl)acetate
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