(4-Aminophenyl)acetic acid

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Names

[ CAS No. ]:
1197-55-3

[ Name ]:
(4-Aminophenyl)acetic acid

[Synonym ]:
UNII:1IED47A544
(4-AMINO-PHENYL)-ACETIC ACID
4-aminophenyl-acetic acid
4-Aminobenzeneacetic acid
p-Aminophenylacetic Acid
4-(AMINOPHENYL)ACETIC ACID
2-(4-aminophenyl)acetic acid
(4-AMINOPHENYL)ACETICACID
Phenylglycine base
MFCD00007916
4-AMINOPHENYLACETIC ACID FOR SYNTHESIS
(4-AMINOPHENYL)ACETIC ACID
EINECS 214-828-7
4-Aminophenylacetic acid
H-4-APH-OH
4-Carboxymethylaniline
RARECHEM AL BO 0220
Benzeneacetic acid, 4-amino-
BENZENEACETICACID, 4-AMINO-
4-Aminophenylacetic
DL-Phenylglycine
(para-Aminophenyl)acetic acid
Desacetyl Actarit
4-AMino acid

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
344.0±17.0 °C at 760 mmHg

[ Melting Point ]:
201 °C (dec.)(lit.)

[ Molecular Formula ]:
C8H9NO2

[ Molecular Weight ]:
151.163

[ Flash Point ]:
161.9±20.9 °C

[ Exact Mass ]:
151.063324

[ PSA ]:
63.32000

[ LogP ]:
0.22

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.615

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AF3550000
CHEMICAL NAME :
Acetic acid, (p-aminophenyl)-
CAS REGISTRY NUMBER :
1197-55-3
BEILSTEIN REFERENCE NO. :
2208094
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C8-H9-N-O2
MOLECULAR WEIGHT :
151.18
WISWESSER LINE NOTATION :
ZR D1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
2500 ug/plate
REFERENCE :
DEMAEP Dental Materials. (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.1- 1985- Volume(issue)/page/year: 2,163,1986

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
AF3550000

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Nitrophenylacetic acid
  • 4-Nitrophenylacetonitrile
  • morpholine
  • 4-Aminoacetophenone
  • 4-(2-nitroethyl)benzenamine
  • 2-[4-(2,5-dimethylpyrrol-1-yl)benzilidene]-1,3-dithian
  • 1-(4-bromophenyl)-2,5-dimethyl-1H-pyrrole
  • [4-(2,5-DIMETHYL-1H-PYRROL-1-YL)PHENYL]-ACETIC ACID
  • 4-(2,5-Dimethyl-1H-pyrrol-1-yl)benzenecarbaldehyde
  • 4-Bromoaniline

DownStream

  • (4-acetamidophenyl) 2-(4-acetamidophenyl)acetate
  • Methyl 2-(4-aminophenyl)acetate
  • (4-Cyanophenyl)acetic acid
  • 2-(4-Bromophenyl)acetyl chloride
  • ethyl 4-ethoxyphenylacetate
  • 4-ethoxyphenylacetic acid
  • Ethyl p-aminophenylacetate
  • 4-mercaptophenylacetic acid
  • (4-Tetrazol-1-yl-phenyl)-acetic acid
  • 4-Fluorophenylacetic acid

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

4-aminomethylbenzoic acid is a non-translocated competitive inhibitor of the epithelial peptide transporter PepT1.

J. Physiol. 512 ( Pt 3) , 629-34, (1998)

1. 4-Aminomethylbenzoic acid, a molecule which mimics the special configuration of a dipeptide, competitively inhibits peptide influx in both Xenopus Laevis oocytes expressing rabbit PepT1 and through...

Preparation of 4-aminophenylacetic acid derivatives with promising antimicrobial activity.

Acta. Pharm. 56(3) , 273-84, (2006)

Condensation of 4-aminophenylacetic acid with phthalic anhydride gave (dioxoisoindolin-2-yl)phenylacetic acid (1), which was employed as the key intermediate in the synthesis of title compounds 2-8. T...

Peptide mimics as substrates for the intestinal peptide transporter.

J. Biol. Chem. 273(1) , 20-2, (1998)

4-Aminophenylacetic acid (4-APAA), a peptide mimic lacking a peptide bond, has been shown to interact with a proton-coupled oligopeptide transporter using a number of different experimental approaches...


More Articles

Related Compounds

  • (4-Aminophenyl)acetic acid
  • 2-(4-aminophenyl)acetic acid
  • (2R)-Amino(4-aminophenyl)acetic acid
  • (4-aminophenyl)acetic acid methyl ester
  • 2-(4-aminophenyl)acetic acid,hydrochloride
  • (2R)-Amino(4-aminophenyl)acetic acid dihydrochloride
  • 5-Bromo-2-[3-(2-chloro-phenyl)-ureido]-benzoic acid
  • 3-(Difluoromethyl)-4-(oxan-4-ylmethoxy)aniline
  • (6-Amino-3-pyridinyl)(2,6-dimethyl-4-morpholinyl)methanone
  • 2-amino-4-chloro-N-(4-(dimethylamino)benzyl)benzamide
  • 3-Amino-7-aza-bicyclo[2.2.1]heptane-2,7-dicarboxylic acid 7-tert-butyl ester 2-methyl ester
  • 6-chloro-2,5-dimethyl-N-phenylpyrimidin-4-amine
  • L-Leucine, glycyl-L-phenylalanyl-, ethyl ester
  • (3-Bromobiphenyl-4-ylethynyl)-tert-butyldimethylsilane
  • 1-Fluoro-2-methyl-4-(2-nitroethenyl)benzene
  • 4-(Cyclohexyloxy)-3-(difluoromethyl)aniline
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