Purine, 2-amino-6- (methylthio)-

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Names

[ Name ]:
Purine, 2-amino-6- (methylthio)-

[Synonym ]:
2-Amino-6-methylthiopurine
6-Methylthioguanine
6-(Methylsulfanyl)-7H-purin-2-amine
Purine, 2-amino-6- (methylthio)-
S-methylthioguanine
6-(Methylsulfanyl)-1H-purin-2-amine
2-Amino-6-methylmercaptopurine
EINECS 214-833-4
1H-Purin-2-amine, 6- (methylthio)-
6-(methylsulfanyl)-7H-purin-2-ylamine
7H-Purin-2-amine, 6-(methylthio)-
MFCD00044701
1H-purin-2-amine, 6-(methylthio)-

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
622.1±58.0 °C at 760 mmHg

[ Melting Point ]:
234-237ºC

[ Molecular Formula ]:
C₆H₇N₅S

[ Molecular Weight ]:
181.218

[ Flash Point ]:
330.0±32.3 °C

[ Exact Mass ]:
181.042221

[ PSA ]:
105.78000

[ LogP ]:
0.82

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.761

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H315-H318-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
24/25-39-26

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Liquid Chromatography with Amperometric Detection at a Silver Based Detector for the Determination of Thiocompounds: Application to the Assay of Thiopurine Antimetabolites in Urine.

Anal. Chem. 87 , 6730-5, (2015)

A silver amperometric detector coupled to liquid chromatography (LC) was used for the determination of 6-thioguanine (6-TG) and two of its metabolites, thiouric acid (TU) and 2-amino-6-mercaptopurine ...

The syntheses and properties of tricyclic pyrrolo[2,3-d]pyrimidine analogues of S6-methylthioguanine and O6-methylguanine.

Org. Biomol. Chem. 4(9) , 1723-9, (2006)

The syntheses of novel tricyclic pyrrolo[2,3-d]pyrimidine analogues of S6-methylthioguanine are described. The crystal structures and pKa values of these and related O6-methylguanine analogues are rep...

Reference intervals for thiopurine S-methyltransferase activity in red blood cells using 6-thioguanine as substrate and rapid non-extraction liquid chromatography.

Ann. Clin. Biochem. 41(Pt 4) , 303-8, (2004)

Although widely used, thiopurine drugs have a narrow therapeutic index and treatment can result in life-threatening toxicity, the basis being pharmacogenetic variation in thiopurine metabolism by thio...

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