4-Phenyl-2-pyrrolidinone

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Names

[ CAS No. ]:
1198-97-6

[ Name ]:
4-Phenyl-2-pyrrolidinone

[Synonym ]:
4-phenylpyrrolidin-2-one
2-Pyrrolidinone, 4-phenyl-
4-Phenyl-2-pyrrolidinone

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
362.3±31.0 °C at 760 mmHg

[ Melting Point ]:
96 °C

[ Molecular Formula ]:
C10H11NO

[ Molecular Weight ]:
161.200

[ Flash Point ]:
212.4±9.8 °C

[ Exact Mass ]:
161.084061

[ PSA ]:
29.10000

[ LogP ]:
0.20

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.551

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UY5912000
CHEMICAL NAME :
2-Pyrrolidinone, 4-phenyl-
CAS REGISTRY NUMBER :
1198-97-6
LAST UPDATED :
198608
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C10-H11-N-O
MOLECULAR WEIGHT :
161.22
WISWESSER LINE NOTATION :
T5MVTJ DR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
325 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia
REFERENCE :
AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.10- 1962- Volume(issue)/page/year: 23,733,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
352 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - smooth muscle relaxant (mechanism undefined, spasmolytic) Behavioral - changes in motor activity (specific assay) Behavioral - muscle weakness
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 14,776,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
352 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Behavioral - muscle weakness Behavioral - analgesia
REFERENCE :
RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 44,22,1981

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2933790090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • β-(Nitromethyl)benzenepropanoic Acid Methyl Ester
  • (+/-)-4-nitro-3-phenylbutyric acid 4'-(4-nitro-3-phenylbutyryloxymethyl)-[2,2']bipyridinyl-4-ylmethyl ester
  • Methyl cinnamate
  • 3-cyano-3-phenylpropanoic acid ethyl ester
  • ethyl 4-nitro-3-phenylbutanoate
  • Ethyl benzylidenemalonate
  • 2-OXO-4-PHENYL-PYRROLIDINE-3-CARBOXYLIC ACID
  • Ethyl 2-oxo-4-phenylpyrrolidine-3-carboxylate
  • Phenylboronic acid
  • Ethyl cinnamate

DownStream

  • Phenibut
  • 3-phenyl-3,4-dihydro-2H-pyrrol-5-amine
  • 3-Amino-4-phenylbutyric acid hydrochloride
  • Carphedon
  • 2-Oxo-4-phenyl-3-pyrrolidinecarboxylic acid
  • 2-Oxo-4-phenyl-1-pyrrolidineacetic Acid Ethyl Ester
  • 3H-Pyrrolo(1,2-a)imidazol-3-one, 2,5,6,7-tetrahydro-2-methyl-6-phenyl-
  • 2,5,6,7-Tetrahydro-2-(1-methylethyl)-6-phenyl-3H-pyrrolo(1,2-a)imidazo l-3-one
  • 2,5,6,7-Tetrahydro-2,6-diphenyl-3H-pyrrolo(1,2-a)imidazol-3-one
  • 2,5,6,7-Tetrahydro-6-phenyl-2-(phenylmethyl)-3H-pyrrolo(1,2-a)imidazol-3-one

Customs

[ HS Code ]: 2933790090

[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

Related Compounds

  • (R)-4-phenyl-2-pyrrolidinone
  • 1-Nicotinoyl-4-phenyl-2-pyrrolidinone
  • (+/-)-5,5-dicarbethoxy-4-phenyl-2-pyrrolidinone
  • 4-benzyl-5-hydroxy-1-methyl-4-phenyl-2-pyrrolidinone
  • 1-(4-(Chlorophenoxy)acetyl)-4-phenyl-2-pyrrolidinone
  • (+)-(R)-1-tert-Butoxycarbonyl-4-phenyl-2-pyrrolidinone
  • 5-Hydroxy-5-[2-[4-(3-nitrophenyl)phenyl]-2-oxoethyl]-1,3-diazinane-2,4,6-trione
  • 6-chloro-N'-[3-(3-fluorophenyl)-4,5-dihydro-1,2-oxazole-5-carbonyl]pyridine-3-carbohydrazide
  • Ethyl 2-[2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)acetamido]-1,3-thiazole-4-carboxylate
  • 2,5-dichloro-N-(1-(tetrahydrofuran-3-yl)-1H-pyrazol-4-yl)benzenesulfonamide
  • 6-(3-Chlorophenyl)piperidin-2-one
  • 4-(1,2,3,4-Tetrahydronaphthalen-1-yl)butan-2-one
  • N-butyl-3-fluoro-5-methylaniline
  • 6-Chloro-N-[4-(3-fluorophenyl)oxan-4-YL]pyridine-3-carboxamide
  • N-(2-(5-Chloro-1H-indol-3-yl)ethyl)-3-(phenylamino)benzamide
  • N-(2-(5-Chloro-1H-indol-3-yl)ethyl)-4-(3-fluorobenzyl)benzamide
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