Grepafloxacin

Suppliers

Names

[ CAS No. ]:
119914-60-2

[ Name ]:
Grepafloxacin

[Synonym ]:
1-cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
1-cyclopropyl-5-methyl-6-fluoro-7-(3-methylpiperazin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
1-Cyclopropyl-6-fluoro-7-(3-methyl-1-piperazinyl)-5-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
MFCD00865116

Chemical & Physical Properties

[ Density]:
1.366

[ Boiling Point ]:
610ºC at 760mmHg

[ Melting Point ]:
189-192ºC

[ Molecular Formula ]:
C19H22FN3O3

[ Molecular Weight ]:
359.39500

[ Flash Point ]:
322.7ºC

[ Exact Mass ]:
359.16500

[ PSA ]:
74.57000

[ LogP ]:
2.67400

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VB1993785
CHEMICAL NAME :
3-Quinolinecarboxylic acid, 1,4-dihydro-1-cyclopropyl-6-fluoro-5-methyl-7-(3-meth yl- 1-piperazinyl)-4-oxo-
CAS REGISTRY NUMBER :
119914-60-2
LAST UPDATED :
199606
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C19-H22-F-N3-O3
MOLECULAR WEIGHT :
359.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
78 mg/kg
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 22,4531,1994

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Methylpiperazine
  • 1-CYCLOPROPYL-6,7-DIFLUORO-5-METHYL-4-OXO-3-QUINOLINE CARBOXYLIC ACID

DownStream

Related Compounds

  • Grepafloxacin
  • Grepafloxacin hydrochloride
  • Grepafloxacin hydrochloride
  • 2-(2-{[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)spiro[3.3]heptan-2-yl]formamido}ethoxy)acetic acid
  • (3RS,4RS)-1-[(3R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pentanoyl]-4-methylpyrrolidine-3-carboxylic acid
  • 3-[(3R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pentanamido]-2-fluorobenzoic acid
  • (2R)-1-(2-{3-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclobutyl}acetyl)pyrrolidine-2-carboxylic acid
  • (1rs,3rs)-3-[(4S)-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-5,5,5-trifluoropentanamido]cyclobutane-1-carboxylic acid
  • 4-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutaneamido]benzoic acid
  • 4-{[1-benzyl-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)piperidin-4-yl]formamido}hexanoic acid
  • rac-(1R,3S)-3-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]cyclohexane-1-carboxylic acid
  • (2S)-1-[4-(dimethylamino)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoyl]-2-methylpyrrolidine-2-carboxylic acid
  • 2-[3-({[1-benzyl-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pyrrolidin-3-yl]formamido}methyl)cyclobutyl]acetic acid
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