3,4-Dimethoxyphenethylamine

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Names

[ CAS No. ]:
120-20-7

[ Name ]:
3,4-Dimethoxyphenethylamine

[Synonym ]:
3,4-Dimethoxyphenethylamine
3,4-Dimethoxyphenylethylamine
2-(3,4-Dimethoxyphenyl)ethanamine
3,4-Dimethoxy phenethylamine
EINECS 204-376-9
2-(3,4-Dimethoxyphenyl)-Ethylamine
3,4-Dimethoxyphenethylamine, Pract.
Benzeneethanamine, 3,4-dimethoxy-
MFCD00008188
2-(3,4-Dimethoxyphenyl)ethylamine
Homoveratrylamine
β-(3,4-Dimethoxyphenyl)ethylamine

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
324.1±0.0 °C at 760 mmHg

[ Melting Point ]:
12-15 °C

[ Molecular Formula ]:
C10H15NO2

[ Molecular Weight ]:
181.232

[ Flash Point ]:
132.8±30.4 °C

[ Exact Mass ]:
181.110275

[ PSA ]:
44.48000

[ LogP ]:
1.20

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.518

[ Storage condition ]:
Refrigerator

[ Water Solubility ]:
SOLUBLE

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SH2300000
CHEMICAL NAME :
Phenethylamine, 3,4-dimethoxy-
CAS REGISTRY NUMBER :
120-20-7
BEILSTEIN REFERENCE NO. :
0474393
LAST UPDATED :
199710
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C10-H15-N-O2
MOLECULAR WEIGHT :
181.26
WISWESSER LINE NOTATION :
Z2R CO1 DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
181 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 97,1117,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04483

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
UN 2735

[ WGK Germany ]:
3

[ RTECS ]:
SH2300000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
29222900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Benzene,1,2-dimethoxy-4-(2-nitroethenyl)-
  • 3,4-Dimethoxyphenylacetonitrile
  • (1S,4R)-2-(3,4-dimethoxyphenethyl)-2-azabicyclo[2.2.1]hept-5-ene hydrochloride
  • veratraldehyde
  • N-[2-(3,4-dimethoxyphenyl)ethyl]-2,2,2-trifluoroacetamide
  • 3 4-DIMETHOXYPHENETHYL BROMIDE
  • (3,4-Dimethoxyphenyl)acetaldehyde
  • 3,4-Dimethoxybenzyl chloride
  • 1,2-Dimethoxybenzene

DownStream

  • 6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-ol
  • 2-(CHLOROACETYL)-6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE
  • 2,2-dichloro-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethanone
  • 6-[2-(3,4-dimethoxyphenyl)ethylamino]-5,5-diethylpyrimidine-2,4-dione
  • palmatine
  • Bevantolol hydrochloride
  • 6,7-Dimethoxy-1-methyl-3,4-dihydroisoquinoline
  • (R)-(+)-Tetrahydropapaverine
  • (1S)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
  • N-Methyl-N-(3-chloropropyl)-3,4-dimethoxy benzenethylamine

Customs

[ HS Code ]: 2922299090

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

New efficient substrates for semicarbazide-sensitive amine oxidase/VAP-1 enzyme: analysis by SARs and computational docking.

J. Med. Chem. 49 , 6197-208, (2006)

Structure activity relationships for semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1) were studied using a library of arylalkylamine substrates, with the aim of contribut...

Effects of acute or chronic administration of novel 3,4-dimethoxyphenylethylamine derivates on anxiety-like behavior.

Am. J. Transl. Res. 7 , 2462-73, (2016)

Novel anxiolytic medications are necessary to broaden treatment therapy. Thus, the aim of the present study was to compare the clinically effective anxiolytic, diazepam with the novel 3,4-dimethoxyphe...

Org. Prep. Proced. Int. 25 , 91, (1993)


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Related Compounds

  • 3,4-dimethoxyphenethylamine hydrochloride
  • N,N-di-(n-propyl)-3,4-dimethoxyphenethylamine
  • N-chloro-N-cyclobutyl-3,4-dimethoxyphenethylamine
  • N-Methyl-N-(3-chloropropyl)-3,4-dimethoxyphenethylamine
  • 2-chloro-N-[2-(1,1-dimethylethoxy)-2-(4-methoxyphenyl)ethyl]-3,4-dimethoxyphenethylamine
  • 3-[4-(dimethylamino)phenyl]-1,5-diphenylpentane-1,5-dione