N-Carbethoxy Piperazine

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Names

[ CAS No. ]:
120-43-4

[ Name ]:
N-Carbethoxy Piperazine

[Synonym ]:
N-Carbethoxy Piperazine
Ethyl N-Piperazinecarboxylate
1-Piperazinecarboxylic acid, ethyl ester
1-Ethoxycarbonylpiperazine
Ethyl Piperazine-1-Carboxylate
MFCD00005964
1-Piperazinecarboxylic Acid Ethyl Ester
EINECS 204-395-2
Ethyl 1-piperazinecarboxylate

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
237.0±15.0 °C at 760 mmHg

[ Melting Point ]:
120 °C

[ Molecular Formula ]:
C7H14N2O2

[ Molecular Weight ]:
158.198

[ Flash Point ]:
97.1±20.4 °C

[ Exact Mass ]:
158.105530

[ PSA ]:
41.57000

[ LogP ]:
-0.14

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.467

[ Water Solubility ]:
soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TL1378000
CHEMICAL NAME :
1-Piperazinecarboxylic acid, ethyl ester
CAS REGISTRY NUMBER :
120-43-4
BEILSTEIN REFERENCE NO. :
0125780
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C7-H14-N2-O2
MOLECULAR WEIGHT :
158.23
WISWESSER LINE NOTATION :
T6M DNTJ AVO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
138 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - muscle contraction or spasticity
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 33,825,1987

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S23-S24/25-S37/39-S26

[ RIDADR ]:
UN 2810 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
TL1378000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
29335995

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • ethyl 4-benzylpiperazine-1-carboxylate
  • bis-cyanomethyl-carbamic acid ethyl ester
  • Piperazine
  • Ethyl chloroformate
  • 1-CARBETHOXYIMIDAZOLE
  • piperazine dihydrochloride
  • JS-K

DownStream

  • 1-(3,4,5-TRIMETHOXYPHENYL)BUTANE-1,3-DIONE
  • 2-(piperazin-1-yl)-acetic acid H2O
  • 1-Isopropylpiperazine
  • Piperazine,1-(tetrahydro-2H-pyran-4-yl)-(9CI)
  • 1-(3-Methylbenzyl)piperazine
  • ethyl 4-prop-2-ynylpiperazine-1-carboxylate
  • 4-(4,5-Diphenyl-2-oxazolyl)-1-piperazinecarboxylic acid ethyl ester
  • 1-Piperazinecarboxylic acid,4-(aminothioxomethyl)-,ethyl ester
  • ethyl 4-phenacylpiperazine-1-carboxylate
  • 1-propylpiperazine

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Antitumor activity of JS-K [O2-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate] and related O2-aryl diazeniumdiolates in vitro and in vivo.

J. Med. Chem. 49 , 4356-66, (2006)

The literature provides evidence that metabolic nitric oxide (NO) release mediates the cytotoxic activities (against human leukemia and prostate cancer xenografts in mice) of JS-K, a compound of struc...


More Articles

Related Compounds

  • N-carbethoxy cyanamide
  • N-Carbethoxy-4-(2-hydroxy-ethyl)-8-methoxy-1,2,3,4-tetrahydro-benzoisochinolin
  • N-carbethoxy-N-methylanthranilic acid
  • N-Carbethoxy-4-amino-piperidone
  • N-carbethoxy-S-methylpseudothiourea
  • N-carbethoxy-N'-(4-methylphenyl)urea
  • 1-benzyl-3-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methylbut-2-enamido]pyrrolidine-3-carboxylic acid
  • 1-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoyl]-1,2,3,6-tetrahydropyridine-4-carboxylic acid
  • 1-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methylbutanoyl]-1,2,3,6-tetrahydropyridine-4-carboxylic acid
  • 1-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pentanoyl]-1,2,3,6-tetrahydropyridine-4-carboxylic acid
  • 2-[2-(cyclopropylmethyl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanamido]-3-methoxy-2-methylpropanoic acid
  • (2S)-4-[2-cyclobutyl-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanamido]-2-hydroxybutanoic acid
  • (2S)-2-[2-cyclobutyl-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanamido]-4-hydroxybutanoic acid
  • (2R)-2-[2-cyclobutyl-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanamido]-4-hydroxybutanoic acid
  • rac-2-{[(1R,2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclopentyl]formamido}-2-(thiophen-2-yl)acetic acid
  • rac-(1R,3S)-3-[2-cyclobutyl-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanamido]cyclopentane-1-carboxylic acid
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