4-Bromocinnamic acid

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Names

[ CAS No. ]:
1200-07-3

[ Name ]:
4-Bromocinnamic acid

[Synonym ]:
3-(4-Bromophenyl)acrylic acid
TRANS-4-BROMOCINNAMIC ACID
2-Propenoic acid, 3-(4-bromophenyl)-, (2E)-
4-BROMO CINNAMIC ACID
4-Bromocinnamic Acid,Predominantly Trans
(2E)-3-(4-Bromophenyl)acrylic acid
2-Propenoic acid, 3-(4-bromophenyl)-
4-bromocinnacid
4-bromo-trans-cinnamic acid
3-(4-bromophenyl)propanoic acid
4-Bromocinnamicacid
(E)-3-(3-bromophenyl)acrylic acid
MFCD00004394
(2E)-3-(4-bromophenyl)prop-2-enoic acid
2-PROPENOICACID, 3-(4-BROMOPHENYL)-
RARECHEM BK HD C006
3-(4-BROMO-PHENYL)-ACRYLICACID
BROMOCINNAMIC ACID,4
EINECS 214-850-7
p-Bromocinnamic acid
4-BroMocinnaMic acid 5GR
4-Bromocinnamic Acid, Predominantly trans
4-Bromobenzeneacrylic acid

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
344.9±17.0 °C at 760 mmHg

[ Melting Point ]:
260-265 °C

[ Molecular Formula ]:
C9H7BrO2

[ Molecular Weight ]:
227.055

[ Flash Point ]:
162.4±20.9 °C

[ Exact Mass ]:
225.962936

[ PSA ]:
37.30000

[ LogP ]:
3.30

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.648

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UD3110000
CHEMICAL NAME :
2-Propenoic acid, 3-(4-bromophenyl)-
CAS REGISTRY NUMBER :
1200-07-3
BEILSTEIN REFERENCE NO. :
1939350
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C9-H7-Br-O2
MOLECULAR WEIGHT :
227.07

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>250 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Behavioral - rigidity (including catalepsy)
REFERENCE :
IJSIDW Indian Journal of Pharmaceutical Sciences. (Kalina, Santa Cruz (East), Bombay 400 029, India) V.40(2)- 1978- Volume(issue)/page/year: 49,77,1987

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S36/37/39-S26-S22

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
UD3110000

[ HS Code ]:
2916399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Malonic acid
  • 4-Bromobenzaldehyde
  • tert-butyl (E)-3-(4-bromophenyl)prop-2-enoate
  • bis(4-bromophenyl)iodonium bromide
  • Acrylic acid
  • Ethanoic anhydride
  • Cinnamic acid
  • (2E)-3-(4-Bromophenyl)acrylaldehyde
  • 2-(4-BROMO-BENZYL)-MALONIC ACID
  • 4-Bromoaniline

DownStream

  • 3-(4-BROMOPHENYL)-2-PROPEN-1-OL
  • 3-Amino-3-(4-bromophenyl)propanoic acid
  • H-Phe(4-Br)-OH
  • 4-Bromo-D-Phe-OH
  • Methyl 3-(4-bromophenyl)acrylate
  • 4-Bromobenzaldehyde
  • Glyoxylic acid
  • 2-Propenoyl chloride, 3-(4-bromophenyl)-
  • 3-(4-BROMOPHENYL)PROPIONALDEHYDE
  • 2,4′-dibromoacetophenone

Customs

[ HS Code ]: 2916399090

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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Tetrahedron Lett. 49(45) , 6429-32, (2008)


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Related Compounds

  • 4-bromocinnamic acid
  • 4-Bromocinnamic acid
  • 4-Bromocinnamic acid ethyl ester
  • (E)-4-bromocinnamic acid chloride
  • (E)-4-bromocinnamic acid methyl ester
  • 4-octanoyloxybenzenesulfonic acid
  • 2-(3-(2,5-dimethoxyphenyl)-6-oxopyridazin-1(6H)-yl)-N-((tetrahydrofuran-2-yl)methyl)acetamide
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • 2-(3-((2-chlorobenzyl)sulfonyl)-1H-indol-1-yl)-N-(3-(trifluoromethyl)phenyl)acetamide
  • 4-Bromo-3-methoxymethoxyphenol