donepezil

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Names

[ CAS No. ]:
120014-06-4

[ Name ]:
donepezil

[Synonym ]:
2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one
5,6-Dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-2,3-dihydro-1H-inden-1-one
n-1-one
2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-
Aricept
Donepezil hydrochloride monohydrate
(±)-E-2020
2-[(1-Benzyl-4-piperidinyl)methyl]-5,6-dimethoxy-1-indanone
2-[(1-Benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one
MFCD00912833
donepezil
1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE
5,6-Dimethoxy-2,3-dihydro-1H-inden-1-one
Donezepil
2-[(1-Benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-on
Donepezil Base

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
527.9±50.0 °C at 760 mmHg

[ Melting Point ]:
207ºC

[ Molecular Formula ]:
C24H29NO3

[ Molecular Weight ]:
379.492

[ Flash Point ]:
273.1±30.1 °C

[ Exact Mass ]:
379.214752

[ PSA ]:
38.77000

[ LogP ]:
4.71

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.578

[ Water Solubility ]:
2.931 mg/L

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
UN 2811

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Benzyl bromide
  • 5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one
  • 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine
  • 2-[(1-Benzylpiperidin-4-yl)hydroxyMethyl]-5,6-dimethoxyindan-1-one
  • Benzyl chloride
  • 1-[(1-benzoylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one
  • 5-[(1-benzyl-4-piperidyl)methyl]-5-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione
  • 5,6-Dimethoxy-1-indanone
  • 1-Benzylpiperidine-4-carbaldehyde
  • p-Formylpyridine

DownStream

  • 6-O-Desmethyl Donepezil
  • Dihydro Donepezil
  • 5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one
  • Donepezil Hydrochloride

Related Compounds

  • Donepezil
  • donepezil
  • 4-Bromothieno[2,3-b]pyridine-2-carbonitrile
  • Thieno[3,2-c]pyridine 4-Methylbenzenesulfonate
  • Ethyl 2-methyl-5-(trifluoromethyl)-1H-indole-3-carboxylate
  • 3-[4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl]piperidine-2,6-dione
  • 3-(4-phenyl-1H-1,2,3-triazol-1-yl)-2,6-Piperidinedione
  • 3-(Difluoromethyl)-2-fluoro-5-nitrobenzoic acid
  • Ethyl 1,3-bis(4-chlorophenyl)-4-hydroxy-2-oxo-5-phenylimidazolidine-4-carboxylate
  • 4-[5-(3-amino-4-hydroxyphenyl)-2H-tetrazol-2-yl]butanoic acid
  • 5-(1,3-Bis(4-chlorophenyl)-4-hydroxy-5,5-dimethyl-2-oxoimidazolidin-4-yl)nicotinonitrile
  • 1-{(E)-[(3-mercapto-5-phenyl-4H-1,2,4-triazol-4-yl)imino]methyl}-2-naphthol
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