AVL-292

Suppliers

Names

[ CAS No. ]:
1202757-89-8

[ Name ]:
AVL-292

[Synonym ]:
N-{3-[(5-Fluoro-2-{[4-(2-methoxyethoxy)phenyl]amino}-4-pyrimidinyl)amino]phenyl}acrylamide
UNII-DRU6NG543J
S7173,CC-292
AVL 292
N-(3-(5-fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide
Spebrutinib
2-Propenamide, N-[3-[[5-fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-
AVL-292

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C22H22FN5O3

[ Molecular Weight ]:
423.440

[ Exact Mass ]:
423.170654

[ PSA ]:
104.12000

[ LogP ]:
2.95

[ Index of Refraction ]:
1.655

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • N4-(3-aminophenyl)-5-fluoro-N2-(4-(2-methoxyethoxy)phenyl)pyrimidine-2,4-diamine
  • Acrylyl chloride

DownStream

Related Compounds

  • AVL-292 (benzenesulfonate)
  • 1-Tetradecanaminium, N,N-dimethyl-N-[2-oxo-2-(2-phenoxyethoxy)ethyl]-, ar-branched nonyl derivs., chlorides
  • LOXO-292
  • Amides, tallow, hydrogenated, N-[2-[4,5-dihydro-2-(hydrogenated nortallow alkyl)-1H-imidazol-1-yl]ethyl], acetates
  • 1,3,5-Triazine-1,3,5(2H,4H,6H)-tripropanamine, N,N,N',N',N'',N''-hexamethyl-, C12-14-alkyl chloride-quaternized
  • Amides, C16-20 and C16-20-unsatd., N-[2-[2-(C15-19 and C15-19-unsatd. alkyl)-4,5-dihydro-1H-imidazol-1-yl]ethyl]