Dorzolamide

Suppliers

Names

[ CAS No. ]:
120279-96-1

[ Name ]:
Dorzolamide

[Synonym ]:
(4S,6S)-4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide
(4S,6S)-4H-Thieno[2,3-b]thiopyran-2-sulfonamide (4-(ethylamino)-5,6-dihydro-6-methyl
1cil
Trusopt
MFCD00865636

Chemical & Physical Properties

[ Density]:
1.53 g/cm3

[ Boiling Point ]:
575.8ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₆N₂O₄S₃

[ Molecular Weight ]:
324.44

[ Flash Point ]:
302ºC

[ PSA ]:
151.33000

[ LogP ]:
4.66680

[ Index of Refraction ]:
1.626

[ Storage condition ]:
room temp

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
S24/25-S37/39-S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ RTECS ]:
UQ1355000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

5,6-Dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-4-one
(4R,6S)-6-Methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-ol
(S)-3-(THIOPHEN-2-YLTHIO)BUTANOIC ACID
(S)-METHYL 3-(THIOPHEN-2-YLTHIO)BUTANOATE
5,6-dihydro-(R,S)-4-hydroxy-(S)-6-methyl-4H-thieno[2,3-b]thiopyran 7,7-dioxide
(S)-6-methyl-6H-thieno[2,3-b]thiopyran 7,7-dioxide

DownStream

Articles

Dorzolamide synergizes the antitumor activity of mitomycin C against Ehrlich's carcinoma grown in mice: role of thioredoxin-interacting protein.

Naunyn Schmiedebergs Arch. Pharmacol. 388 , 1271-82, (2015)

The antitumor activity of carbonic anhydrase (CA) inhibitors is attributed to their ability to induce a state of intracellular acidification. In fact, acidic intracellular pH was demonstrated to upreg...

Synaptic pathology and therapeutic repair in adult retinoschisis mouse by AAV-RS1 transfer.

J. Clin. Invest. 125 , 2891-903, (2015)

Strategies aimed at invoking synaptic plasticity have therapeutic potential for several neurological conditions. The human retinal synaptic disease X-linked retinoschisis (XLRS) is characterized by im...

Bleb Analysis and Short-Term Results of Biodegradable Collagen Matrix-Augmented Ahmed Glaucoma Valve Implantation: 6-Month Follow-up.

Invest. Ophthalmol. Vis. Sci. 56 , 5896-903, (2015)

To evaluate the short-term efficacy of a biodegradable collagen matrix (BCM) as an adjuvant for Ahmed valve implantation surgery to prevent the hypertensive phase.This prospective study included 43 re...

dorzolamide
Dorzolamide
dorzolamide
dorzolamide
dorzolamide
Dorzolamide-d5
2-{4-[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylpentanoyl]morpholin-3-yl}acetic acid
3-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methoxypropanamido]bicyclo[2.2.1]heptane-2-carboxylic acid
2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3,3,3-trifluoro-2-methylpropanamido]-2-methylpentanoic acid
(2S)-2-{2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]-4-methylpentanamido}-3-methylpentanoic acid
tert-butyl N-[2-(2-chloro-6-methoxyphenyl)-1-oxopropan-2-yl]carbamate
2,2-Difluoro-3-(3-fluoropiperidin-1-yl)propanoic acid
3-{N-ethyl-2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]-4-methylpentanamido}-2-methylpropanoic acid
(4R)-3-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cycloheptanecarbonyl]-1,3-thiazolidine-4-carboxylic acid
tert-butyl N-[2-(4,4-difluorocyclohexyl)-1-oxopropan-2-yl]-N-methylcarbamate
2-({2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]-4-methylpentanamido}methyl)-3-methylbutanoic acid

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