Dorzolamide

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Names

[ CAS No. ]:
120279-96-1

[ Name ]:
Dorzolamide

[Synonym ]:
(4S,6S)-4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide
(4S,6S)-4H-Thieno[2,3-b]thiopyran-2-sulfonamide (4-(ethylamino)-5,6-dihydro-6-methyl
1cil
Trusopt
MFCD00865636

Chemical & Physical Properties

[ Density]:
1.53 g/cm3

[ Boiling Point ]:
575.8ºC at 760 mmHg

[ Molecular Formula ]:
C10H16N2O4S3

[ Molecular Weight ]:
324.44

[ Flash Point ]:
302ºC

[ PSA ]:
151.33000

[ LogP ]:
4.66680

[ Index of Refraction ]:
1.626

[ Storage condition ]:
room temp

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
S24/25-S37/39-S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ RTECS ]:
UQ1355000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 5,6-Dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-4-one
  • (4R,6S)-6-Methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-ol
  • (S)-3-(THIOPHEN-2-YLTHIO)BUTANOIC ACID
  • (S)-METHYL 3-(THIOPHEN-2-YLTHIO)BUTANOATE
  • 5,6-dihydro-(R,S)-4-hydroxy-(S)-6-methyl-4H-thieno[2,3-b]thiopyran 7,7-dioxide
  • (S)-6-methyl-6H-thieno[2,3-b]thiopyran 7,7-dioxide

DownStream

  • Dorzolamide hydrochloride

Articles

Dorzolamide synergizes the antitumor activity of mitomycin C against Ehrlich's carcinoma grown in mice: role of thioredoxin-interacting protein.

Naunyn Schmiedebergs Arch. Pharmacol. 388 , 1271-82, (2015)

The antitumor activity of carbonic anhydrase (CA) inhibitors is attributed to their ability to induce a state of intracellular acidification. In fact, acidic intracellular pH was demonstrated to upreg...

Synaptic pathology and therapeutic repair in adult retinoschisis mouse by AAV-RS1 transfer.

J. Clin. Invest. 125 , 2891-903, (2015)

Strategies aimed at invoking synaptic plasticity have therapeutic potential for several neurological conditions. The human retinal synaptic disease X-linked retinoschisis (XLRS) is characterized by im...

Bleb Analysis and Short-Term Results of Biodegradable Collagen Matrix-Augmented Ahmed Glaucoma Valve Implantation: 6-Month Follow-up.

Invest. Ophthalmol. Vis. Sci. 56 , 5896-903, (2015)

To evaluate the short-term efficacy of a biodegradable collagen matrix (BCM) as an adjuvant for Ahmed valve implantation surgery to prevent the hypertensive phase.This prospective study included 43 re...


More Articles

Related Compounds

  • dorzolamide
  • Dorzolamide
  • dorzolamide
  • dorzolamide
  • dorzolamide
  • Dorzolamide-d5
  • 1-(1-Cyclopropylcyclopropyl)ethan-1-amine
  • 2-(4-Methoxy-3-nitrophenyl)cyclopropan-1-amine
  • [3-(5-Fluoropyridin-2-yl)-2,2-dimethylcyclopropyl]methanamine
  • 4-{2-[(4-Methylpiperidin-4-yl)oxy]ethyl}morpholine
  • 2-Amino-2-[4-(methoxycarbonyl)-3-methylphenyl]acetic acid
  • 2-(3-Methoxypyridin-2-yl)cyclopropane-1-carboxylic acid
  • 4-(2-Methoxy-1,3-thiazol-5-yl)butan-2-amine
  • 3-Amino-3-[5-(methoxycarbonyl)thiophen-2-yl]propanoic acid
  • O-[(3-methylpyridin-4-yl)methyl]hydroxylamine
  • 3-Amino-3-(2,4,6-trihydroxyphenyl)propanoic acid
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