Dorzolamide
Suppliers
Names
[ CAS No. ]:
120279-96-1
        
[ Name ]:
 Dorzolamide
        
[Synonym ]:
                
                (4S,6S)-4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide
                
                
            
                
                (4S,6S)-4H-Thieno[2,3-b]thiopyran-2-sulfonamide (4-(ethylamino)-5,6-dihydro-6-methyl
                
                
            
                
                1cil
                
                
            
                
                Trusopt
                
                
            
                
                MFCD00865636
                
                
                
                
    
Chemical & Physical Properties
[ Density]:
1.53 g/cm3
            
[ Boiling Point ]:
575.8ºC at 760 mmHg
            
[ Molecular Formula ]:
C10H16N2O4S3
            
[ Molecular Weight ]:
324.44
            
[ Flash Point ]:
302ºC
            
[ PSA ]:
151.33000
            
[ LogP ]:
4.66680
            
[ Index of Refraction ]:
1.626
            
[ Storage condition ]:
room temp
            
MSDS
Safety Information
[ Symbol ]:
                
                
                GHS07
            
[ Signal Word ]: 
Warning
            
[ Hazard Statements ]:
 H315-H319-H335
            
[ Precautionary Statements ]:
 P261-P305 + P351 + P338
            
[ Hazard Codes ]:
 Xi
            
[ Risk Phrases ]:
 R36/37/38:Irritating to eyes, respiratory system and skin .
            
[ Safety Phrases ]:
 S24/25-S37/39-S26
            
[ RIDADR ]: 
NONH for all modes of transport
            
[ WGK Germany ]: 
1
            
[ RTECS ]: 
UQ1355000
            
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Naunyn Schmiedebergs Arch. Pharmacol. 388 , 1271-82, (2015)
The antitumor activity of carbonic anhydrase (CA) inhibitors is attributed to their ability to induce a state of intracellular acidification. In fact, acidic intracellular pH was demonstrated to upreg...
J. Clin. Invest. 125 , 2891-903, (2015)
Strategies aimed at invoking synaptic plasticity have therapeutic potential for several neurological conditions. The human retinal synaptic disease X-linked retinoschisis (XLRS) is characterized by im...
Invest. Ophthalmol. Vis. Sci. 56 , 5896-903, (2015)
To evaluate the short-term efficacy of a biodegradable collagen matrix (BCM) as an adjuvant for Ahmed valve implantation surgery to prevent the hypertensive phase.This prospective study included 43 re...