leinamycin

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Names

[ CAS No. ]:
120500-15-4

[ Name ]:
leinamycin

Chemical & Physical Properties

[ Density]:
1.48g/cm3

[ Molecular Formula ]:
C₂₂H₂₆N₂O₆S₃

[ Molecular Weight ]:
510.64700

[ Exact Mass ]:
510.09500

[ PSA ]:
206.41000

[ LogP ]:
3.57130

[ Index of Refraction ]:
1.68

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WH1306540

CHEMICAL NAME :: Spiro(1,2-dithiolane-3,6'-(19)thia(3,20)diazabicyclo( 15.2.1)eicosa(1(20),9 ,13,15,17) pentaene)-4',5,12'-trione, 4,11'-dihydroxy-2',4,9'-trimethyl-, 2-oxide

CAS REGISTRY NUMBER :: 120500-15-4

LAST UPDATED :: 199406

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C22-H26-N2-O6-S3

MOLECULAR WEIGHT :: 510.68

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 42,333,1989

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

(2E,4Z,8E)-4',7-dihydroxy-4',9,16-trimethylspiro[18-thia-15,20-diazabicyclo[15.2.1]icosa-1(19),2,4,8,17(20)-pentaene-12,5'-dithiolane]-3',6,14-trione
4-Thiazolecarboxylicacid,2-(1-hydroxyethyl)-,ethylester,(S)-(9CI)
(R)-2-(1-azidoethyl)-4-ethynylthiazole
(2E,5Z)-3-methoxy-3-oxopropyl 3-((2S,4R)-2-(tert-butyl)-4-methyl-5-oxo-1,3-dioxolan-4-yl)-8-(ethylthio)-6-methyl-8-oxoocta-2,5-dienoate

DownStream