leinamycin

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Names

[ CAS No. ]:
120500-15-4

[ Name ]:
leinamycin

Chemical & Physical Properties

[ Density]:
1.48g/cm3

[ Molecular Formula ]:
C22H26N2O6S3

[ Molecular Weight ]:
510.64700

[ Exact Mass ]:
510.09500

[ PSA ]:
206.41000

[ LogP ]:
3.57130

[ Index of Refraction ]:
1.68

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WH1306540
CHEMICAL NAME :
Spiro(1,2-dithiolane-3,6'-(19)thia(3,20)diazabicyclo( 15.2.1)eicosa(1(20),9 ,13,15,17) pentaene)-4',5,12'-trione, 4,11'-dihydroxy-2',4,9'-trimethyl-, 2-oxide
CAS REGISTRY NUMBER :
120500-15-4
LAST UPDATED :
199406
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C22-H26-N2-O6-S3
MOLECULAR WEIGHT :
510.68

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 42,333,1989

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (2E,4Z,8E)-4',7-dihydroxy-4',9,16-trimethylspiro[18-thia-15,20-diazabicyclo[15.2.1]icosa-1(19),2,4,8,17(20)-pentaene-12,5'-dithiolane]-3',6,14-trione
  • 4-Thiazolecarboxylicacid,2-(1-hydroxyethyl)-,ethylester,(S)-(9CI)
  • (R)-2-(1-azidoethyl)-4-ethynylthiazole
  • (2E,5Z)-3-methoxy-3-oxopropyl 3-((2S,4R)-2-(tert-butyl)-4-methyl-5-oxo-1,3-dioxolan-4-yl)-8-(ethylthio)-6-methyl-8-oxoocta-2,5-dienoate

DownStream

Related Compounds

  • 7-bromo-3-[(cyclopropylamino)methyl]-1,4-dimethyl-1H-indole-2-carbonitrile
  • 3-[(cyclopropylamino)methyl]-1-methyl-4-(trifluoromethoxy)-1H-indole-2-carbonitrile
  • [5-cyclobutyl-1-(pentan-3-yl)-1H-1,2,3-triazol-4-yl]methanol
  • [5-cyclobutyl-1-(2,2,2-trifluoroethyl)-1H-1,2,3-triazol-4-yl]methanol
  • rac-tert-butyl (3R,4R)-3-hydroxy-4-(1-methyl-1H-imidazol-4-yl)pyrrolidine-1-carboxylate
  • 4-(5-Methoxythiophen-2-yl)pyrrolidin-3-ol
  • rac-(1R,2S)-2-(1-methyl-1H-1,2,4-triazol-3-yl)cyclohexan-1-ol
  • 2-[(3-Bromopyridin-2-yl)methyl]cyclobutan-1-ol
  • 2-(2,5-dimethyl-1H-pyrrol-3-yl)-1-propylpyrrolidin-3-amine
  • 2-(1H-imidazol-2-yl)-1-propylpyrrolidin-3-amine
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