Anastrozole

Suppliers

Names

[ CAS No. ]:
120511-73-1

[ Name ]:
Anastrozole

[Synonym ]:
Anastrozole
ICI-D-1033
ZD-1033
2,2'-5-(1H-1,2,4-triazol-1-ylmethyl)benzene-1,3-diylbis(2-methylpropanenitrile)
Anastrol
MFCD00866298
1,3-Benzenediacetonitrile, α,α,α',α'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-
2,2'-[5-(1H-1,2,4-Triazol-1-ylmethyl)-1,3-phenylene]bis(2-methylpropanenitrile)
ICI D 1033
1,3-benzenediacetonitrile
2,2'-[5-(1H-1,2,4-triazol-1-ylméthyl)benzène-1,3-diyl]bis(2-méthylpropanenitrile)
2,2'-[5-(1H-1,2,4-Triazol-1-ylmethyl)benzol-1,3-diyl]bis(2-methylpropanonitril)
ANASTRAZOLE
2,2'-(5-((1H-1,2,4-Triazol-1-yl)methyl)-1,3-phenylene)bis(2-methylpropanenitrile)
4-Triazol-1-ylmethyl)-1
Anastrolozole
Anatrozole
a,a,a',a'-Tetramethyl-5-(1H-,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile
Anastrozol
ARIMIDEX

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
469.7±55.0 °C at 760 mmHg

[ Melting Point ]:
81-82°C

[ Molecular Formula ]:
C₁₇H₁₉N₅

[ Molecular Weight ]:
293.366

[ Flash Point ]:
237.9±31.5 °C

[ Exact Mass ]:
293.164032

[ PSA ]:
78.29000

[ LogP ]:
0.97

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.580

[ Storage condition ]:
Store at RT

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H360

[ Precautionary Statements ]:
P201-P280-P301 + P312 + P330-P308 + P313

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-37/39

[ RIDADR ]:
3249

[ RTECS ]:
CZ1465000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

1,2,4-Triazole
3,5-Bis(2-cyanoprop-2-yl)benzyl bromide
1,2,4-Triazolylsodium
Pentamethyl-1,3-benzenediacetonitrile
anastrozole mesylate
2-[3-(chloromethyl)-5-(2-cyanopropan-2-yl)phenyl]-2-methylpropanenitrile
2,2'-[5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene]-di(2-methylpropionitrile) hydrobromide
Anastrozole EP Impurity E
1-(4-Methylphenylsulfonyl)-1,2,4-triazole

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Changes in bone mineral density at 3 years in postmenopausal women receiving anastrozole and risedronate in the IBIS-II bone substudy: an international, double-blind, randomised, placebo-controlled trial.

Lancet Oncol. 15(13) , 1460-8, (2014)

Aromatase inhibitors prevent breast cancer in postmenopausal women at high risk of the disease but are associated with accelerated bone loss. We assessed effectiveness of oral risedronate for preventi...

NSAID use reduces breast cancer recurrence in overweight and obese women: role of prostaglandin-aromatase interactions.

Cancer Res. 74(16) , 4446-57, (2014)

Obesity is associated with a worse breast cancer prognosis and elevated levels of inflammation, including greater cyclooxygenase-2 (COX-2) expression and activity in adipose-infiltrating macrophages. ...

Impact of BMI on serum estradiol and bone turnover markers in postmenopausal women with hormone-sensitive early breast cancer treated with anastrozole.

J. Cancer Res. Clin. Oncol. 140(1) , 159-66, (2014)

Obesity increases the risk of all-cause and breast cancer mortality. As obese patients have higher levels of aromatase enzyme activity, conflicting results on the effect of body mass index (BMI) of a ...

forAnastrozole
Anastrozole-d12
anastrozole mesylate
Anastrozole Mono Acid
Anastrozole Impurity 7
Anastrozole Impurity 8
N-butyl-2-[4-(6-chloropyridine-3-carbonyl)piperazin-1-yl]acetamide
4-phenyl-N-(1,3-thiazol-2-yl)oxane-4-carboxamide
N-{1-[5-chloro-2-(methylsulfanyl)pyrimidine-4-carbonyl]piperidin-4-yl}benzamide
2-bromo-5-methoxy-N-propylbenzene-1-sulfonamide
5-methoxy-2-methyl-N-propylbenzene-1-sulfonamide
N-(3-bromo-4-methylphenyl)oxane-4-carboxamide
tert-butyl 7'-methoxy-5'H-spiro[piperidine-4,4'-pyrrolo[1,2-a]quinoxaline]-1-carboxylate
4-methyl-5-[3-(1H-pyrrol-1-yl)-2-thienyl]-4H-1,2,4-triazol-3-ylhydrosulfide
4-bromo-N-{3-[5-(trifluoromethyl)pyridin-2-yl]phenyl}benzene-1-sulfonamide
N-{3-[5-(trifluoromethyl)pyridin-2-yl]phenyl}benzenesulfonamide

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