Roxarsone

[ Boiling Point ]:
537.3±60.0 °C at 760 mmHg

[ Melting Point ]:
≥300 °C(lit.)

[ Molecular Formula ]:
C₆H₆AsNO₆

[ Molecular Weight ]:
263.036

[ Flash Point ]:
240.3±21.3 °C

[ Exact Mass ]:
262.941101

[ PSA ]:
123.58000

[ LogP ]:
-0.51

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Water Solubility ]:
<0.1 g/100 mL at 23 ºC

Click to get detail MSDS

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CY5250000

CHEMICAL NAME :: Benzenearsonic acid, 4-hydroxy-3-nitro-

CAS REGISTRY NUMBER :: 121-19-7

BEILSTEIN REFERENCE NO. :: 1976533

LAST UPDATED :: 199701

DATA ITEMS CITED :: 44

MOLECULAR FORMULA :: C6-H6-As-N-O6

MOLECULAR WEIGHT :: 263.05

WISWESSER LINE NOTATION :: WNR BQ E-AS-QQO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 81 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 66 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Gastrointestinal - other changes Kidney, Ureter, Bladder - interstitial nephritis

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 244 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Liver - hepatitis (hepatocellular necrosis), diffuse Kidney, Ureter, Bladder - hematuria

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Gastrointestinal - other changes Blood - hemorrhage

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 34 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Liver - hepatitis (hepatocellular necrosis), diffuse

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - turkey

DOSE/DURATION :: 61 mg/kg

TOXIC EFFECTS :: Gastrointestinal - other changes Blood - hemorrhage

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2647 mg/kg/13W-C

TOXIC EFFECTS :: Behavioral - food intake (animal) Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 11200 mg/kg/14D-C

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1680 mg/kg/14D-C

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8736 mg/kg/13W-C

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - bronchiolar dilation Liver - changes in liver weight Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 3625 mg/kg/13W-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in bladder weight Blood - hemorrhage Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - turkey

DOSE/DURATION :: 2019 mg/kg/36D-C

TOXIC EFFECTS :: Peripheral Nerve and Sensation - structural change in nerve or sheath Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2920 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 400 mg/L

REFERENCE :: NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-345,1989 *** REVIEWS *** TOXICOLOGY REVIEW 85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77 Volume(issue)/page/year: As,-,1977 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.5 mg(As)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,16,1971 OSHA PEL (Gen Indu):8H TWA 0.5 mg(As)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.5 mg(As)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.5 mg(As)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.5 mg(As)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.2 mg(As)/m3 JAN 1993 OEL-AUSTRALIA:TWA 0.05 mg(As)/m3;Carcinogen JAN 1993 OEL-BELGIUM:TWA 0.2 mg(As)/m3 JAN 1993 OEL-DENMARK:TWA 0.05 mg(As)/m3 JAN 1993 OEL-FINLAND;Carcinogen JAN 1993 OEL-FRANCE:TWA 0.2 mg(As)/m3 JAN 1993 OEL-HUNGARY:STEL 0.5 mg(As)/m3;Carcinogen JAN 1993 OEL-INDIA:TWA 0.2 mg(As)/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 0.5 mg(As)/m3 JAN 1993 OEL-POLAND:TWA 0.3 mg(As)/m3 JAN 1993 OEL-SWEDEN:TWA 0.03 mg(As)/m3;Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 0.1 mg(As)/m3;Carcinogen JAN 1993 OEL-THAILAND:TWA 0.5 mg(As)/m3 JAN 1993 OEL-TURKEY:TWA 0.5 mg(As)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.2 mg(As)/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0637 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 124 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0637 No. of Facilities: 210 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 3230 (estimated)

[ Symbol ]:

GHS06, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301 + H331-H410

[ Precautionary Statements ]:
P261-P273-P301 + P310-P311-P501

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic;N:Dangerousfortheenvironment;

[ Risk Phrases ]:
R23/25;R50/53

[ Safety Phrases ]:
20/21-28-45-60-61

[ RIDADR ]:
UN 3465 6.1/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
CY5250000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2931900029

Click to get detail synthetic route

Precursor

4-Hydroxyphenylarsonic Acid
Phenol
(4-amino-3-nitro-phenyl)arsonic acid
(4-dimethylamino-3-nitro-phenyl)-arsonic acid
(4-anilino-3-nitro-phenyl)-arsonic acid
Sulfuric acid
Arsonic acid,(4-chloro-3-nitrophenyl)- (9CI)
Arsonic acid,(4-chlorophenyl)- (9CI)
Arsonic acid,[4-(acetylamino)phenyl]- (9CI)
Arsonic acid,[4-(dimethylamino)phenyl]- (9CI)

DownStream

o-Nitrophenol
ACETARSONE
4-arsoroso-2-nitrophenol
oxophenarsine
4-Iodo-2-nitrophenol
Arsonic acid,As-(3-amino-4-hydroxyphenyl)-
Dichlorophenarsine
4-HYDROXY-3,5-DINITROBENZENEARSONIC ACID

[ HS Code ]: 2931900029

[ Summary ]:
2931900029 (4-hydroxy-3-nitrophenyl)arsonic acid。supervision conditions:x(environment control release notice for poisonous chemicals)。VAT:17.0%。tax rebate rate:0.0%。MFN tarrif:6.5%。general tariff:30.0%

Degradation of roxarsone in a silt loam soil and its toxicity assessment.

Chemosphere 112 , 128-33, (2014)

The land application of poultry or swine litter, containing large amounts of roxarsone, causes serious arsenic pollution in soil. Understanding biotransformation process of roxarsone and its potential...

Retention of phenylarsenicals in soils derived from volcanic materials.

J. Hazard. Mater. 186(2-3) , 1328-34, (2011)

Sorption of phenylarsenicals including 4-hydroxy-3-nitrophenylarsonic acid (roxarsone), an animal feed additive widely used for growth stimulation, on soils was investigated in batch systems. Phenylar...

Characterization of Salmonella enterica isolates from turkeys in commercial processing plants for resistance to antibiotics, disinfectants, and a growth promoter.

Foodborne Pathog. Dis. 8(5) , 593-600, (2011)

Salmonella enterica isolates from turkeys in two commercial processing plants (1 and 2) were characterized for susceptibility to antibiotics, disinfectants, and the organoarsenical growth promoter, 4-...

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Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synthetic Route

Click to get detail synthetic route

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