N,N-Dimethylaniline
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Names
[ CAS No. ]:
121-69-7
[ Name ]:
N,N-Dimethylaniline
[Synonym ]:
N,N-Dimethylbenzeneamine
aniline, N,N-dimethyl-
dimethylphenylamine
dimethylaniline
Benzenamine,N,N-dimethyl
N,N-Dimethylbenzenamine
N,N-Dimethylphenylamine
MFCD00008304
N,N-Dimethylaniline
Aniline,N,N-dimethyl
phenyldimethylamine
Benzenamine, N,N-dimethyl-
Dimethylaniline, N,N-
N,N-dimethyl-Benzenamine
Dimethylaniline, N-N-
N,N-DIMETHYL-ANILINE
EINECS 204-493-5
Chemical & Physical Properties
[ Density]:
1.0±0.1 g/cm3
[ Boiling Point ]:
193.5±0.0 °C at 760 mmHg
[ Melting Point ]:
1.5-2.5 °C(lit.)
[ Molecular Formula ]:
C8H11N
[ Molecular Weight ]:
121.180
[ Flash Point ]:
62.8±0.0 °C
[ Exact Mass ]:
121.089149
[ PSA ]:
3.24000
[ LogP ]:
2.33
[ Vapour density ]:
3 (vs air)
[ Vapour Pressure ]:
0.5±0.3 mmHg at 25°C
[ Index of Refraction ]:
1.550
[ Stability ]:
Stable. Incompatible with strong oxidizing agents, strong acids, acid chlorides, acid anhydrides, chloroformates, halogens. Combustible.
[ Water Solubility ]:
1 g/L (20 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- BX4725000
- CHEMICAL NAME :
- Aniline, N,N-dimethyl-
- CAS REGISTRY NUMBER :
- 121-69-7
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 58
- MOLECULAR FORMULA :
- C8-H11-N
- MOLECULAR WEIGHT :
- 121.20
- WISWESSER LINE NOTATION :
- 1N1&R
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Open irritation test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting Gastrointestinal - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1410 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 250 mg/m3/4H
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - excitement
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 350 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1770 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 32500 mg/kg/13W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes Blood - changes in spleen Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 16250 mg/kg/13W-I
- TOXIC EFFECTS :
- Liver - other changes Blood - changes in bone marrow (not otherwise specified) Blood - changes in spleen
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10700 ug/m3/5H/17W-I
- TOXIC EFFECTS :
- Blood - pigmented or nucleated red blood cells Blood - methemoglobinemia-carboxyhemoglobin Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 300 ug/m3/24H/14W-C
- TOXIC EFFECTS :
- Behavioral - muscle contraction or spasticity Blood - methemoglobinemia-carboxyhemoglobin Blood - changes in erythrocyte (RBC) count
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 32500 mg/kg/13W-I
- TOXIC EFFECTS :
- Blood - changes in spleen
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 32500 mg/kg/13W-I
- TOXIC EFFECTS :
- Liver - other changes Kidney, Ureter, Bladder - other changes Blood - changes in spleen
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 15450 mg/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 15450 mg/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - tumors
- TYPE OF TEST :
- DNA damage
- TYPE OF TEST :
- DNA damage
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Ovary
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 13,60,1989 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-STEL 50 mg/m3 (10 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 25 mg/m3 (5 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,337,1993 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,337,1993 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,337,1993 *** U.S. STANDARDS AND REGULATIONS *** OSHA PEL (Gen Indu):8H TWA 5 ppm (25 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 5 ppm (25 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 5 ppm (25 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 5 ppm (25 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 5 ppm (25 mg/m3);STEL 10 ppm (50 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 5 ppm (25 mg/m3);STEL 10 ppm (50 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 5 ppm (25 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 5 ppm (25 mg/m3);STEL 10 ppm (50 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 5 ppm (25 mg/m3);Skin JAN 1993 OEL-GERMANY:TWA 5 ppm (25 mg/m3) JAN 1993 OEL-HUNGARY:TWA 5 mg/m3;STEL 10 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 5 ppm (25 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 5 ppm (25 mg/m3) JAN 1993 OEL-POLAND:TWA 5 mg/m3 JAN 1993 OEL-RUSSIA:STEL 0.2 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (25 mg/m3);STEL 10 ppm (50 mg/m3);Skin JAN 1993 OEL-UNITED KINGDOM:TWA 5 ppm (25 mg/m3);STEL 10 ppm;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO DIMETHYLANILINE-air:10H TWA 5 ppm (Sk);STEL 10 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 26335 No. of Facilities: 100 (estimated) No. of Industries: 4 No. of Occupations: 10 No. of Employees: 2456 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 26335 No. of Facilities: 1428 (estimated) No. of Industries: 15 No. of Occupations: 27 No. of Employees: 30480 (estimated) No. of Female Employees: 7448 (estimated)
Safety Information
[ Symbol ]:
GHS06, GHS08, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301 + H311 + H331-H351-H411
[ Precautionary Statements ]:
P261-P273-P280-P301 + P310 + P330-P302 + P352 + P312-P403 + P233
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
T:Toxic
[ Risk Phrases ]:
R23/24/25;R40;R51/53
[ Safety Phrases ]:
S53-S45-S61-S36/37-S28A-S28
[ RIDADR ]:
UN 2253 6.1/PG 2
[ WGK Germany ]:
3
[ RTECS ]:
BX4725000
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1
[ HS Code ]:
2921492000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2921492000
[ Summary ]:
2921492000 n,n-dimethylaniline。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:6.5%。General tariff:20.0%
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