2-Chloro-4-nitroaniline
Suppliers
Names
[ CAS No. ]:
121-87-9
[ Name ]:
2-Chloro-4-nitroaniline
[Synonym ]:
ocpn
2-Chloro-4-nitrobenzenamine
2-chloro-4-nitrophenylamine
1-Amino-2-chloro-4-nitrobenzene
o-chloro-nitroaniline
EINECS 204-502-2
4-NITRO-2-CHLOROANILINE
2-chloro-4-nitro-aniline
MFCD00007665
2-Chlor-4-nitroanilin
ZR BG DNW
2-Chloro-4-nitroaniline
OCPNA
Benzenamine, 2-chloro-4-nitro-
2-/-4-CHLORONITROANILIN
2-chloro-4-nitro-anilin
2-Chloro-4-nitroanil
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Boiling Point ]:
326.2±22.0 °C at 760 mmHg
[ Melting Point ]:
107 °C
[ Molecular Formula ]:
C6H5ClN2O2
[ Molecular Weight ]:
172.569
[ Flash Point ]:
151.1±22.3 °C
[ Exact Mass ]:
172.003952
[ PSA ]:
71.84000
[ LogP ]:
2.46
[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C
[ Index of Refraction ]:
1.646
[ Stability ]:
Stable. Incompatible with strong oxidizing agents, strong bases, strong acids.
[ Water Solubility ]:
0.23 g/L (20 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- BX1400000
- CHEMICAL NAME :
- Aniline, 2-chloro-4-nitro-
- CAS REGISTRY NUMBER :
- 121-87-9
- BEILSTEIN REFERENCE NO. :
- 0638657
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 12
- MOLECULAR FORMULA :
- C6-H5-Cl-N2-O2
- MOLECULAR WEIGHT :
- 172.58
- WISWESSER LINE NOTATION :
- ZR BG DNW
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 6430 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 56 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 1800 mg/kg
- TOXIC EFFECTS :
- Behavioral - general anesthetic
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 1 mg/plate
- REFERENCE :
- SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959- Volume(issue)/page/year: 29,34,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0882 No. of Facilities: 708 (estimated) No. of Industries: 12 No. of Occupations: 9 No. of Employees: 2937 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0882 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 737 (estimated)
Safety Information
[ Symbol ]:
GHS07, GHS09
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H411
[ Precautionary Statements ]:
P273
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn:Harmful
[ Risk Phrases ]:
R22;R51/53
[ Safety Phrases ]:
S22-S24-S61
[ RIDADR ]:
UN 2237 6.1/PG 3
[ WGK Germany ]:
2
[ RTECS ]:
BX1400000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
[ HS Code ]:
2921420090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2921420090
[ Summary ]:
HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
Articles
Med. Lav. 82(3) , 253-60, (1991)
The toxicity of 4-chloro-2-nitroaniline (4C2NA) and 2-chloro-4-nitroaniline (2C4NA) was investigated on isolated rat hepatocytes following 1-3 hours of exposure to 0.2 and/or 2 mM of these xenobiotics...
Mutat. Res. 264(3) , 139-45, (1991)
Niclosamide is an anti-helminthic drug susceptible to being metabolized into a bacterial mutagen by the action of enzymes present in the S9 activation mixture. Additional results from genotoxic studie...
J. AOAC Int. 76(2) , 287-91, (1993)
A method is described for the determination of the intermediates and a related impurity in D&C Red No. 36 by reversed-phase liquid chromatography. This method may be used to ensure that limits set for...