Alpelisib (BYL719)

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Names

[ CAS No. ]:
1217486-61-7

[ Name ]:
Alpelisib (BYL719)

[Synonym ]:
UNII:08W5N2C97Q
1,2-Pyrrolidinedicarboxamide, N-[4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-, (2S)-
QCR-1
BYL719
(S)-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-{4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-yl}amide
(2S)-N-{4-Methyl-5-[2-(1,1,1-trifluoro-2-methyl-2-propanyl)-4-pyridinyl]-1,3-thiazol-2-yl}-1,2-pyrrolidinedicarboxamide
Alpelisib
(2S)-N1 -{4-methyl-5-[1-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin- 4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide
BYL-719

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C19H22F3N5O2S

[ Molecular Weight ]:
441.470

[ Exact Mass ]:
441.144623

[ PSA ]:
133.93000

[ LogP ]:
-0.02

[ Index of Refraction ]:
1.587

[ Storage condition ]:
-20℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • L-Prolinamide
  • N-(4-Methyl-5-(2-(1,1,1-Trifluoro-2-Methylpropan-2-Yl)Pyridin-4-Yl)Thiazol-2-Yl)-1H-Imidazole-1-Carboxamide
  • 2,4-Lutidine
  • 1-(4-Methyl-2-pyridinyl)ethanone
  • 4-Methyl-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine
  • 4-methyl-2-(2,2,2-trifluoro-1-methyl-1-trimethylsilanyloxy-ethyl)pyridine

DownStream

Related Compounds

  • Alpelisib hydrochloride
  • Proline
  • 4-{[(4-Methoxyphenyl)methyl](methyl)amino}pyridine-2-carboxamide
  • 2-(8'-(Hydroxymethyl)-3,3-dimethyl-6'-nitrospiro[indoline-2,2'-thiochromen]-1-yl)ethanol
  • N-{4-[(1-Methylpyridin-4(1H)-ylidene)amino]phenyl}-4-[(1-methylquinolin-4(1H)-ylidene)amino]benzene-1-carboximidic acid--4-methylbenzene-1-sulfonic acid (1/2)
  • 3-(2-Bromo-5-hydroxyphenyl)propanenitrile
  • (2S,10S)-15-methyl-15-azatetracyclo[10.2.1.02,10.04,9]pentadeca-4,6,8-triene;hydrochloride
  • Anacetrapib metabolite M3
  • (1S,4R)-4-(dimethylamino)-1-phenyl-3,4-dihydro-2H-naphthalene-1-carbonitrile;hydrochloride
  • Mercury 2-amino-4-sulfanylbutanoate methanide (1/1/1)
  • Oxalic acid--Nalpha-[(benzyloxy)(hydroxy)methylidene]-O-[2-(dimethylamino)ethyl]-N,N-dipropyltyrosinamide (1/1)
  • 12-Methyl-5a,6,7,8,9,10,10a,11-octahydro-5H-6,9-epiminocyclohepta[b]naphthalen-5-one--hydrogen chloride (1/1)
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