Alpelisib (BYL719)

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Names

[ Name ]:
Alpelisib (BYL719)

[Synonym ]:
UNII:08W5N2C97Q
1,2-Pyrrolidinedicarboxamide, N-[4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-, (2S)-
QCR-1
BYL719
(S)-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-{4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-yl}amide
(2S)-N-{4-Methyl-5-[2-(1,1,1-trifluoro-2-methyl-2-propanyl)-4-pyridinyl]-1,3-thiazol-2-yl}-1,2-pyrrolidinedicarboxamide
Alpelisib
(2S)-N1 -{4-methyl-5-[1-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin- 4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide
BYL-719

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₁₉H₂₂F₃N₅O₂S

[ Molecular Weight ]:
441.470

[ Exact Mass ]:
441.144623

[ PSA ]:
133.93000

[ LogP ]:
-0.02

[ Index of Refraction ]:
1.587

[ Storage condition ]:
-20℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

L-Prolinamide
N-(4-Methyl-5-(2-(1,1,1-Trifluoro-2-Methylpropan-2-Yl)Pyridin-4-Yl)Thiazol-2-Yl)-1H-Imidazole-1-Carboxamide
2,4-Lutidine
1-(4-Methyl-2-pyridinyl)ethanone
4-Methyl-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine
4-methyl-2-(2,2,2-trifluoro-1-methyl-1-trimethylsilanyloxy-ethyl)pyridine