6-bromoflavone

Names

[ Name ]:
6-bromoflavone

[Synonym ]:
6-Bromoflavone
6-bromo-2-phenyl-4H-1-benzopyran-4-one
6-bromo-2-phenyl-chromen-4-one
6-bromo-2-phenyl-4H-chromen-4-one
MFCD00276169
6-Brom-2-phenyl-chromen-4-on

Chemical & Physical Properties

[ Density]:
1.54g/cm3

[ Boiling Point ]:
421.1ºC at 760 mmHg

[ Melting Point ]:
193-196ºC(lit.)

[ Molecular Formula ]:
C₁₅H₉BrO₂

[ Molecular Weight ]:
301.13500

[ Flash Point ]:
208.5ºC

[ Exact Mass ]:
299.97900

[ PSA ]:
30.21000

[ LogP ]:
4.22250

[ Vapour Pressure ]:
2.67E-07mmHg at 25°C

[ Index of Refraction ]:
1.656

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2914700090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Phenylacetylene
5-Bromosalicylaldehyde
6-bromoflavanone
1-(5-Bromo-2-hydroxyphenyl)-3-phenyl-1,3-propanedione
2-Propen-1-one,1-(5-bromo-2-hydroxyphenyl)-3-phenyl-
5'-Bromo-2'-hydroxyacetophenone
Benzoyl chloride
2-Propen-1-one,1-(3-bromophenyl)-3-phenyl-, (2E)-

DownStream

3,6-dibromo-2-phenylchromen-4-one
2,6-diphenylchromen-4-one
benzoic acid

Customs

[ HS Code ]: 2914700090

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

Articles

6-Bromoflavone, a high affinity ligand for the central benzodiazepine receptors is a member of a family of active flavonoids. Marder M, et al.

Biochem. Biophys. Res. Commun. 223(2) , 384-389, (1996)

Reaction of 2'-hydroxychalcone dibromides with pyridine. Reddy NJ, et al.

J. Org. Chem. 46(3) , 638-641., (1981)

6-isothiocyanato-6-pentylundecane
6-Iodo-3-pyridinamine
6-phenylpyridazine-3-carboxylic acid
6,6,6-trifluoro-5-hydroxy-2,2-dimethyl-5-(trifluoromethyl)hexan-3-one
6,9-Dihydro-7,8-dihydroxy-6,9-dioxo-2-phenazinecarboxylic acid
6-aminoundecanoic acid
3-(3,5-Dimethylisoxazol-4-yl)-1-(3-(3-methyl-1,2,4-oxadiazol-5-yl)-4-phenylpyrrolidin-1-yl)propan-1-one
Cyclopropyl(3-(3-methyl-1,2,4-oxadiazol-5-yl)-4-phenylpyrrolidin-1-yl)methanone
2-Methoxy-1-(3-(3-methyl-1,2,4-oxadiazol-5-yl)-4-phenylpyrrolidin-1-yl)ethanone
(3-(3-Methyl-1,2,4-oxadiazol-5-yl)-4-phenylpyrrolidin-1-yl)(o-tolyl)methanone
2-(1H-imidazol-1-yl)-1-(3-(3-methyl-1,2,4-oxadiazol-5-yl)-4-phenylpyrrolidin-1-yl)ethanone
(2,4-Dimethylthiazol-5-yl)(3-(3-methyl-1,2,4-oxadiazol-5-yl)-4-phenylpyrrolidin-1-yl)methanone
(2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)(3-(3-methyl-1,2,4-oxadiazol-5-yl)-4-phenylpyrrolidin-1-yl)methanone
(3-methoxy-1-methyl-1H-pyrazol-4-yl)(3-(3-methyl-1,2,4-oxadiazol-5-yl)-4-phenylpyrrolidin-1-yl)methanone
(3-(3-Methyl-1,2,4-oxadiazol-5-yl)-4-phenylpyrrolidin-1-yl)(2-methylimidazo[1,2-a]pyridin-3-yl)methanone
(3-(3-Methyl-1,2,4-oxadiazol-5-yl)-4-phenylpyrrolidin-1-yl)(pyridin-4-yl)methanone

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