2-[(Difluoromethyl)sulfonyl]pyridine

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Names

[ CAS No. ]:
1219454-89-3

[ Name ]:
2-[(Difluoromethyl)sulfonyl]pyridine

[Synonym ]:
Difluoromethyl 2-pyridyl sulfone
2-[(Difluoromethyl)sulfonyl]pyridine
Pyridine, 2-[(difluoromethyl)sulfonyl]-
2-(difluoromethylsulfonyl)pyridine

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
324.4±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C6H5F2NO2S

[ Molecular Weight ]:
193.171

[ Flash Point ]:
150.0±27.9 °C

[ Exact Mass ]:
193.000900

[ PSA ]:
55.41000

[ LogP ]:
0.38

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.475

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H319

[ Precautionary Statements ]:
P301 + P310-P305 + P351 + P338

[ Hazard Codes ]:
Xn

[ RIDADR ]:
UN 2811 6.1 / PGIII

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Pyridinethiol

DownStream

  • 2-pyridone
  • 5-(2,2-difluorovinyl)benzo[d][1,3]dioxole
  • 1-(2,2-difluoroethenyl)-4-methoxybenzene
  • 4-(difluoromethylene)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
  • 1-bromo-4-(1,1-difluoroprop-1-en-2-yl)benzene
  • (E)-(4,4-difluoro-3-methylbuta-1,3-dienyl)benzene
  • 1,1-difluoro-2-(3-nitrophenyl)ethene

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Direct synthesis of fluorinated heteroarylether bioisosteres.

Angew. Chem. Int. Ed. Engl. 52 , 3949-3952, (2013)

Difluoromethyl 2-pyridyl sulfone: a new gem-difluoroolefination reagent for aldehydes and ketones.

Org. Lett. 12 , 1444-1447, (2010)

Difluoromethyl 2-pyridyl sulfone, a previously unknown compound, was found to act as a novel and efficient gem-difluoroolefination reagent for both aldehydes and ketones. It was found that the fluorin...

From difluoromethyl 2-pyridyl sulfone to difluorinated sulfonates: a protocol for nucleophilic difluoro(sulfonato)methylation.

Angew. Chem. Int. Ed. Engl. 50 , 2559-2563, (2011)


More Articles

Related Compounds

  • 2-((difluoromethyl)sulfonyl)benzaldehyde
  • 2-[(DIFLUOROMETHYL)SULFONYL]ANILINE HYDROCHLORIDE
  • 2-((Difluoromethyl)sulfonyl)benzo[d]thiazole
  • 2-(Difluoromethyl)pyridine-4-carboxaldehyde, 2-(Difluoromethyl)-4-formylpyridine
  • 2-(Difluoromethyl)pyridine-3-carboxylic acid
  • 2-(Difluoromethyl)pyridine