4-Hydroxydiphenylamine

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Names

[ CAS No. ]:
122-37-2

[ Name ]:
4-Hydroxydiphenylamine

[Synonym ]:
4-anilinophenol
4-HydroxydiphenylaMine
EINECS 204-538-9
p-Anilinophenol
MFCD00020142

Chemical & Physical Properties

[ Density]:
1.203 g/cm3

[ Boiling Point ]:
190°C

[ Melting Point ]:
67-73°C

[ Molecular Formula ]:
C12H11NO

[ Molecular Weight ]:
185.22200

[ Flash Point ]:
209°C

[ Exact Mass ]:
185.08400

[ PSA ]:
32.26000

[ LogP ]:
3.20880

[ Vapour Pressure ]:
8.52E-05mmHg at 25°C

[ Index of Refraction ]:
1.67

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SJ6950000
CHEMICAL NAME :
Phenol, p-anilino-
CAS REGISTRY NUMBER :
122-37-2
BEILSTEIN REFERENCE NO. :
0511942
LAST UPDATED :
199710
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C12-H11-N-O
MOLECULAR WEIGHT :
185.24
WISWESSER LINE NOTATION :
QR DMR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,698,1986 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3300 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - general anesthetic Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 27(3),52,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2120 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,1123,1962
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,1123,1962
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
3300 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 40(10),114,1975 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.5 mg/m3 JAN 1993

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R37/38;R41

[ Safety Phrases ]:
S26-S36/37/39-S36/39

[ RIDADR ]:
UN2811

[ RTECS ]:
SJ6950000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2922299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Bromobenzene
  • 4-Aminophenol
  • Triphenyl phosphite
  • 1,4-Cyclohexanedione
  • Iodobenzene
  • 4-(phenylamino)phenyl acetate
  • phenylmagnesium bromide
  • P-NITROPHENYLACETATE
  • (4-Aminophenyl)acetic acid

DownStream

  • 4-N-[4-(4-anilinoanilino)phenyl]-1-N-phenylbenzene-1,4-diamine
  • 10H-phenothiazin-3-ol
  • N-phenyl-4-propoxyaniline
  • 4-pentoxy-N-phenylaniline
  • Geranyl linalool
  • 2,5-DICHLOROHYDROQUINONE
  • 4-phenyliminocyclohexa-2,5-dien-1-one
  • p-hydroxydiphenylamine radical
  • Benzenamine,4-(1-methylethoxy)-N-phenyl-
  • Phenyl(4-ethoxyphenyl)amine

Customs

[ HS Code ]: 2922299090

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

  • N-acetyl-4-hydroxydiphenylamine
  • 3'-Methyl-4'-amino-4-hydroxydiphenylamine
  • 4-chlorooxolan-3-ol,formic acid
  • 4-Amino-1,2-dithiolane-4-carboxylic acid
  • 4-hydroxy-N-[(4-methoxyphenyl)methylideneamino]benzamide
  • 4(3H)-Quinazolinone,3-[3-[[bis(2-chloroethyl)amino]methyl]-4-methoxyphenyl]-2-methyl-
  • 5-[(4-Ethenylphenyl)methyl]-2-(4-fluorophenyl)-1,2,3,3a-tetrahydropyrazolo[1,5-a]pyrazin-4-one
  • 6-[4-[6-(Dimethylamino)pyridazin-3-yl]piperazin-1-yl]-3-methyl-1,3-diazinane-2,4-dione
  • 2,4-dibenzyl-N-butan-2-yl-1,5-dioxo-3,3a,5a,6,7,8,9,9a-octahydro-[1,2,4]triazolo[4,3-a]quinazoline-8-carboxamide
  • N-[1-(1,3-dimethyl-2,4-dioxo-5H-pyrimidin-1-ium-5-yl)piperidin-4-yl]-3,5-dimethyl-1,2-oxazole-4-carboxamide
  • N-[1-(1,3-dimethyl-2,4-dioxo-5H-pyrimidin-1-ium-5-yl)piperidin-4-yl]-3-fluoropyridine-4-carboxamide
  • 5-(3,4-dimethylanilino)-N-(4-ethylphenyl)triazolidine-4-carboxamide
  • 1,3-Dimethyl-6-[4-(6-morpholin-4-ylpyridazin-3-yl)piperazin-1-yl]-1,3-diazinane-2,4-dione
  • 5-[(4-Chlorophenyl)methyl]-2-(4-fluorophenyl)-1,2,3,3a-tetrahydropyrazolo[1,5-a]pyrazin-4-one
  • 5-[4-[(5-bromopyrimidin-2-yl)amino]piperidin-1-yl]-1,3-dimethyl-5H-pyrimidin-1-ium-2,4-dione
  • N-[1-(1,3-dimethyl-2,4-dioxo-5H-pyrimidin-1-ium-5-yl)piperidin-4-yl]pyridine-4-carboxamide
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