4-CPA

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Names

[ CAS No. ]:
122-88-3

[ Name ]:
4-CPA

[Synonym ]:
parachlorophenoxyacetic acid
Sure-Set
tomatofix
QV1OR DG
4-CPA
EINECS 204-581-3
Acetic acid, (4-chlorophenoxy)-
Acetic acid, 2-(4-chlorophenoxy)-
marks4-cpa
MFCD00004305
4-Chlorophenoxyacetic acid
4-ChFU
2-(4-Chlorophenoxy)acetic acid
4-CP
(4-Chlorophenoxy)acetic acid

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
315.2±17.0 °C at 760 mmHg

[ Melting Point ]:
157-159 °C

[ Molecular Formula ]:
C8H7ClO3

[ Molecular Weight ]:
186.592

[ Flash Point ]:
144.4±20.9 °C

[ Exact Mass ]:
186.008377

[ PSA ]:
46.53000

[ LogP ]:
2.03

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.558

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AG0175000
CHEMICAL NAME :
Acetic acid, (p-chlorophenoxy)-
CAS REGISTRY NUMBER :
122-88-3
BEILSTEIN REFERENCE NO. :
1211804
LAST UPDATED :
199701
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C8-H7-Cl-O3
MOLECULAR WEIGHT :
186.60
WISWESSER LINE NOTATION :
QV1OR DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
850 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
680 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Unscheduled DNA synthesis
TEST SYSTEM :
Human Cells - not otherwise specified
DOSE/DURATION :
10 mmol/L
REFERENCE :
ZYDXDM Zhejiang Yike Daxue Xuebao. Journal of Zhejiang Medical University. (Zhejiang Yike Daxue, Yan'an Lu, Hanzhou, Zhejiang, Peop. Rep. China) V.1- 1972(?)- Volume(issue)/page/year: 13(2),74,1984 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S22

[ RIDADR ]:
2811

[ WGK Germany ]:
1

[ RTECS ]:
AG0175000

[ HS Code ]:
2916399014

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Ethyl p-Chlorophenoxyacetate
  • 4-Chlorophenol
  • Chloroacetic acid
  • Methyl bromoacetate
  • Acetic acid,2-(4-chlorophenoxy)-, methyl ester
  • Sodium chloroacetate
  • 2,4-Dichlorophenoxyacetic acid
  • methyl chloroacetate
  • Phenoxyacetic acid
  • Centrophenoxine hydrochloride

DownStream

  • 3-[[5-[(4-chlorophenoxy)methyl]-1,3,4-oxadiazol-2-yl]methyl]-2-methylquinazolin-4-one
  • 6,8-dibromo-3-[[5-[(4-chlorophenoxy)methyl]-1,3,4-oxadiazol-2-yl]methyl]-2-methylquinazolin-4-one
  • 2-(4-CHLORO-PHENOXY)-1-PIPERAZIN-1-YL-ETHANONE
  • 2-(Dimethylamino)ethyl (4-chlorphenoxy)acetate
  • Acetyl chloride,2-(4-chlorophenoxy)-
  • Centrophenoxine hydrochloride
  • 2,4-Dichlorophenoxyacetic acid
  • 2-(4-chlorophenoxy)-N-methoxy-N-methylacetamide
  • 2-(4-Chloro-2-nitrophenoxy)acetic acid
  • 2-(4-chloro-2-nitrophenoxy)acetamide

Customs

[ HS Code ]: 2916399014

[ Summary ]:
2916399014 。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

Articles

Phenoxy herbicides and fibrates potently inhibit the human chemosensory receptor subunit T1R3.

J. Med. Chem. 52 , 6931-5, (2009)

We show that phenoxyauxin herbicides and lipid-lowering fibrates inhibit human but not rodent T1R3. T1R3 as a coreceptor in taste cells responds to sweet compounds and amino acids; in endocrine cells ...

Amphiphilic blockers punch through a mutant CLC-0 pore.

J. Gen. Physiol. 133(1) , 59-68, (2009)

Intracellularly applied amphiphilic molecules, such as p-chlorophenoxy acetate (CPA) and octanoate, block various pore-open mutants of CLC-0. The voltage-dependent block of a particular pore-open muta...

Molecular modeling of p-chlorophenoxyacetic acid binding to the CLC-0 channel.

Biochemistry 42(18) , 5176-85, (2003)

Molecular simulation techniques were applied to predict the interaction of the CLC-0 Cl(-) channel and the channel-blocking molecule p-chlorophenoxyacetic acid (CPA). A three-dimensional model of the ...


More Articles

Related Compounds

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  • 4-CPA-diolamine
  • 4-chlorooxolan-3-ol,formic acid
  • 4-Amino-1,2-dithiolane-4-carboxylic acid
  • 4-hydroxy-N-[(4-methoxyphenyl)methylideneamino]benzamide
  • 4-nitro-2-[(3-nitrophenyl)methylideneamino]phenol
  • N,3,3-trimethylcyclopentan-1-amine hydrochloride
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • Methyl nonanimidate
  • (3S)-1-amino-5-(4-bromophenyl)pentan-3-ol
  • 3-Bromo-2,6-dichloropyridin-4-amine
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide