2-Anilinoethanol

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Names

[ CAS No. ]:
122-98-5

[ Name ]:
2-Anilinoethanol

[Synonym ]:
Ethanol, 2- (phenylamino)-
β-Anilinoethanol
2-ethanol aniline
N-(2-Hydroxyethyl)aniline
Ethanol,2-anilino
N-(β-hydroxy)ethylaniline
EINECS 204-588-1
Aniline, N-(β-hydroxyethyl)-
N-Phenylethanolamine
Ethanol, 2-(phenylamino)-
2-(phenylamino)ethanol
N-(β-Hydroxyethyl)aniline
2-Anilinoethanol
MFCD00002832
Phenyl ethanolamine
(±)-phenylethanolamine
N-2-hydroxyethylaniline

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
286.9±13.0 °C at 760 mmHg

[ Melting Point ]:
-30 °C

[ Molecular Formula ]:
C₈H₁₁NO

[ Molecular Weight ]:
137.179

[ Flash Point ]:
151.4±10.5 °C

[ Exact Mass ]:
137.084061

[ PSA ]:
32.26000

[ LogP ]:
0.82

[ Vapour density ]:
>1 (vs air)

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.600

[ Water Solubility ]:
53 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KJ7175000

CHEMICAL NAME :: Ethanol, 2-anilino-

CAS REGISTRY NUMBER :: 122-98-5

BEILSTEIN REFERENCE NO. :: 0774672

LAST UPDATED :: 199701

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C8-H11-N-O

MOLECULAR WEIGHT :: 137.20

WISWESSER LINE NOTATION :: Q2MR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 8/21/1961

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,691,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2230 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 8/21/1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 137 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 97,1117,1977

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Vascular - BP elevation not characterized in autonomic section

REFERENCE :: 85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948 Volume(issue)/page/year: -,111,1948

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Vascular - contraction (isolated tissues)

REFERENCE :: JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 123,761,1943

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 165 mg/kg

TOXIC EFFECTS :: Vascular - contraction (isolated tissues)

REFERENCE :: JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 123,761,1943

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 63 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 44 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Behavioral - coma

REFERENCE :: JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 123,761,1943

Safety Information

[ Symbol ]:

GHS05, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H310-H318-H373-H412

[ Precautionary Statements ]:
P273-P280-P302 + P352 + P310-P305 + P351 + P338 + P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T:Toxic;

[ Risk Phrases ]:
R24;R36

[ Safety Phrases ]:
S26-S36/37/39-S45-S28A

[ RIDADR ]:
UN 2810 6.1/PG 2

[ WGK Germany ]:
1

[ RTECS ]:
KJ7175000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

[ HS Code ]:
2922199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Iodobenzene
2-Aminoethanol
Glycolaldehyde
Bromobenzene
Phenylboronic acid
Ethylene carbonate
ETHYLENE OXIDE
2-Indoethanol

DownStream

4-(4-Aminophenyl)morpholin-3-one
indoxyl
N-(2'-Cyanoethyl)-N-(2"-hydroxyethyl)aniline
4-Phenylmorpholine
2-(N-Methylanilino)ethanol
4-(3-Oxo-4-morpholinyl)nitrobenzene
Rivaroxaban
4-[((2R)-Hydroxy-3-phthalimido)propylamine]phenyl-3-morpholinone
2-[N-[2-[N-(2-hydroxyethyl)anilino]ethyl]anilino]ethanol
(R,E)-2-(benzo[d][1,3]dioxol-5-ylmethyleneamino)-2-phenylethanol

Customs

[ HS Code ]: 2922199090

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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