5-[4-(1,2,4,5-Tetrazin-3-yl)benzylamino]-5-oxopentanoic acid

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Names

[ CAS No. ]:
1225146-53-1

[ Name ]:
5-[4-(1,2,4,5-Tetrazin-3-yl)benzylamino]-5-oxopentanoic acid

[Synonym ]:
Bz-Tz-acid

Chemical & Physical Properties

[ Melting Point ]:
163-170°C (decomposition)

[ Molecular Formula ]:
C₁₄H₁₅N₅O₃

[ Molecular Weight ]:
301.3

[ Storage condition ]:
-20°C

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22-36-37-38

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Synthesis and evaluation of a series of 1,2,4,5-tetrazines for bioorthogonal conjugation.

Bioconjug. Chem. 22 , 2263-2270, (2011)

1,2,4,5-Tetrazines have been established as effective dienes for inverse electron demand [4 + 2] Diels-Alder cycloaddition reactions with strained alkenes for over 50 years. Recently, this reaction pa...

Tetrazine-based cycloadditions: application to pretargeted live cell imaging.

Bioconjug. Chem. 19 , 2297-2299, (2008)

Bioorthogonal tetrazine cycloadditions have been applied to live cell labeling. Tetrazines react irreversibly with the strained dienophile norbornene forming dihydropyrazine products and dinitrogen. T...

Tetrazine ligation: fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity.

J. Am. Chem. Soc. 130 , 13518-13519, (2008)

Described is a bioorthogonal reaction that proceeds with unusually fast reaction rates without need for catalysis: the cycloaddition of s-tetrazine and trans-cyclooctene derivatives. The reactions tol...

(Z)-2-(4-phenyl-2-(p-tolylimino)thiazol-3(2H)-yl)ethanol
N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-(4-methyl-7-oxo-1-(o-tolyl)-1H-pyrazolo[3,4-d]pyridazin-6(7H)-yl)acetamide
2-(4-methyl-7-oxo-1-(o-tolyl)-1H-pyrazolo[3,4-d]pyridazin-6(7H)-yl)-N-(2-(trifluoromethyl)phenyl)acetamide
(Z)-2-(4-(3-nitrophenyl)-2-(p-tolylimino)thiazol-3(2H)-yl)ethanol
(Z)-2-(4-(3-methoxyphenyl)-2-(p-tolylimino)thiazol-3(2H)-yl)ethanol
(Z)-2-(4-(thiophen-2-yl)-2-(p-tolylimino)thiazol-3(2H)-yl)ethanol
2-(4-methyl-7-oxo-1-(o-tolyl)-1H-pyrazolo[3,4-d]pyridazin-6(7H)-yl)-N-(3-(trifluoromethyl)phenyl)acetamide
(Z)-2-(4-(3-nitrophenyl)-2-(o-tolylimino)thiazol-3(2H)-yl)ethanol
(Z)-2-(4-(3-methoxyphenyl)-2-(o-tolylimino)thiazol-3(2H)-yl)ethanol
(Z)-1-(3-(2-hydroxyethyl)-4-methyl-2-(o-tolylimino)-2,3-dihydrothiazol-5-yl)ethanone

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