4-o-pivaloyl-3-hydroxy-l-phenylalanine

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Names

[ CAS No. ]:
122551-95-5

[ Name ]:
4-o-pivaloyl-3-hydroxy-l-phenylalanine

[Synonym ]:
3-hydroxy-l-tyrosine4-(2,2-dimethylpropanoate)
PDOPA
PivDOPA
4-O-pivaloyl-L-dopa
L-TYROSINE,3-HYDROXY-,4-(2,2-DIMETHYLPROPANOATE)
4-O-Pivaloyl-L-DOPA L-3-(3-Hydroxy-4-pivaloyloxyphenyl)alanine
nb355
L-3-(3-HYDROXY-4-PIVALOYLOXYPHENYL)ALANINE
3-[3-Hydroxy-4-(pivaloyloxy)phenyl]-L-alanine

Chemical & Physical Properties

[ Density]:
1.184 g/cm3

[ Boiling Point ]:
461.5ºC at 760 mmHg

[ Molecular Formula ]:
C14H19NO5

[ Molecular Weight ]:
281.30400

[ Flash Point ]:
232.9ºC

[ Exact Mass ]:
281.12600

[ PSA ]:
109.85000

[ LogP ]:
1.99840

[ Vapour Pressure ]:
7.28E-09mmHg at 25°C

[ Index of Refraction ]:
1.564

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YP2833780
CHEMICAL NAME :
L-Tyrosine, 3-hydroxy-, 4-(2,2-dimethylpropanoate)
CAS REGISTRY NUMBER :
122551-95-5
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C14-H19-N-O5
MOLECULAR WEIGHT :
281.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 78,525,1989

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Levodopa
  • Pivaloyl chloride

DownStream

Related Compounds

  • 4-Carboxy-3-hydroxy-L-phenylalanine
  • N-(tert-butoxycarbonyl)-4-(2,6-dichlorobenzyloxy)-3-hydroxy-L-phenylalanine methyl ester
  • 6-bromo-m-tyrosine
  • N-Boc-3-hydroxy-L-phenylalanine
  • 3,5-di-O-caffeoyl-4-O-(3-hydroxy-3-methyl)glutaroylquinic acid
  • boc-val-met-ome
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 3-[[(2R,3S)-3-amino-4-oxo-azetidin-2-yl]methyl]oxazolidin-2-one
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 5-((tert-Butoxycarbonyl)amino)cyclohex-1-en-1-yl trifluoromethanesulfonate