XE 991 dihydrochloride

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Names

[ CAS No. ]:
122955-42-4

[ Name ]:
XE 991 dihydrochloride

[Synonym ]:
10,10-bis(pyridin-4-ylmethyl)anthracen-9-one,dihydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
625.3ºC at 760mmHg

[ Molecular Formula ]:
C₂₆H₂₀N₂O

[ Molecular Weight ]:
376.45

[ Flash Point ]:
332ºC

[ Exact Mass ]:
376.15800

[ PSA ]:
42.85000

[ LogP ]:
4.79250

[ Vapour Pressure ]:
6.84E-16mmHg at 25°C

[ Storage condition ]:
2-8°C

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
CB1530000

Articles

Loss of Local Astrocyte Support Disrupts Action Potential Propagation and Glutamate Release Synchrony from Unmyelinated Hippocampal Axon Terminals In Vitro.

J. Neurosci. 35 , 11105-17, (2015)

Neuron-astrocyte interactions are critical for proper CNS development and function. Astrocytes secrete factors that are pivotal for synaptic development and function, neuronal metabolism, and neuronal...

Inhibition of post-synaptic Kv7/KCNQ/M channels facilitates long-term potentiation in the hippocampus.

PLoS ONE 7 , e30402, (2012)

Activation of muscarinic acetylcholine receptors (mAChR) facilitates the induction of synaptic plasticity and enhances cognitive function. In the hippocampus, M(1) mAChR on CA1 pyramidal cells inhibit...

Raised activity of L-type calcium channels renders neurons prone to form paroxysmal depolarization shifts.

Neuromolecular Med. 15 , 476-92, (2013)

Neuronal L-type voltage-gated calcium channels (LTCCs) are involved in several physiological functions, but increased activity of LTCCs has been linked to pathology. Due to the coupling of LTCC-mediat...