Azelaic acid
Suppliers
Names
[ CAS No. ]:
123-99-9
[ Name ]:
Azelaic acid
[Synonym ]:
Skinoren
AZALEIC ACID
Azelaate
3,4-Dimethoxybenzaldehyde
Nonanedioic acid
Azelaic acid
UNII-F2VW3D43YT
AZELAIC ACID/NONANEDIOIC ACID
Barasertib
AZELAIC ACID FOR SYNTHESIS
INH 34
Azelex
Azelaicacid
Finaceae
lepargylic acid
1,7-HEPTANE DICARBONIC ACID
1,7-HEPTANEDICARBOXYLIC
AZD1152-HQPA
Azelainic acid
HEPTANE-1,7-DICARBOXYLIC ACID
Azalaic Acid
AZELAIC ACID( MICRONIZED )
EINECS 204-669-1
anchoic acid
1,7-Heptanedicarboxylic acid
MFCD00004432
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
286 ºC (100 mmHg)
[ Melting Point ]:
98-103 ºC
[ Molecular Formula ]:
C9H16O4
[ Molecular Weight ]:
188.221
[ Flash Point ]:
215 ºC
[ Exact Mass ]:
188.104858
[ PSA ]:
74.60000
[ LogP ]:
1.33
[ Vapour density ]:
6.5 (vs air)
[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C
[ Index of Refraction ]:
1.475
[ Stability ]:
Stable. Combustible. Incompatible with bases, strong oxidizing agents. Readily biodegrades in soil and water with >70% DOC reduction after 28 days.
[ Water Solubility ]:
2.4 g/L (20 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- CM1980000
- CHEMICAL NAME :
- Azelaic acid
- CAS REGISTRY NUMBER :
- 123-99-9
- BEILSTEIN REFERENCE NO. :
- 1101094
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C9-H16-O4
- MOLECULAR WEIGHT :
- 188.25
- WISWESSER LINE NOTATION :
- QV7VQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- EMERY* Emery Industries, Inc., Data Sheets. (4900 Este Ave., Cincinnati, OH 45232) Volume(issue)/page/year: S3B,-,1964
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- EMERY* Emery Industries, Inc., Data Sheets. (4900 Este Ave., Cincinnati, OH 45232) Volume(issue)/page/year: S3B,-,1964 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD-A067-313 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83495 No. of Facilities: 170 (estimated) No. of Industries: 8 No. of Occupations: 11 No. of Employees: 1676 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83495 No. of Facilities: 3427 (estimated) No. of Industries: 35 No. of Occupations: 42 No. of Employees: 34469 (estimated) No. of Female Employees: 7576 (estimated)
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H319
[ Precautionary Statements ]:
P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xi: Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
1
[ RTECS ]:
CM1980000
[ HS Code ]:
2917139000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2917139000
[ Summary ]:
2917139000 azelaic acid, sebacic acid, their salts and esters VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
Articles
J. Sci. Ind. Res. 65(10) , 808, (2006)
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...
J. Inherit. Metab. Dis. 16(4) , 648-69, (1993)
Concentrations of organic acids in cerebrospinal fluid (CSF) appear to be directly dependent upon their rate of production in the brain. There is evidence that the net release of short-chain monocarbo...
Clin. Chem. 40(6) , 862-6, (1994)
Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days...