2-Hydroxyestriol

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Names

[ CAS No. ]:
1232-80-0

[ Name ]:
2-Hydroxyestriol

[Synonym ]:
13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-2,3,16,17-tetrol

Chemical & Physical Properties

[ Density]:
1.334 g/cm3

[ Boiling Point ]:
504.6ºC at 760 mmHg

[ Molecular Formula ]:
C₁₈H₂₄O₄

[ Molecular Weight ]:
304.38100

[ Flash Point ]:
238.4ºC

[ Exact Mass ]:
304.16700

[ PSA ]:
80.92000

[ LogP ]:
2.28560

[ Vapour Pressure ]:
5.3E-11mmHg at 25°C

[ Index of Refraction ]:
1.648

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H351

[ Precautionary Statements ]:
P281

[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R40

[ RIDADR ]:
NONH for all modes of transport

Articles

Simultaneous perfusion of [4-14C]oestriol and [6,9-3H2]oestriol 16 alpha-monoglucuronide through the isolated rat liver. II. Kinetic aspects.

Acta Endocrinol. 100(2) , 274-8, (1982)

The uptake of [4-14C]oestriol by the isolated perfused rat liver is 3.8 times faster as compared to that of simultaneously perfused [6,9-3H2]oestriol 16 alpha-monoglucuronide. During perfusion the con...

Comparison of metabolic ratios of urinary estrogens between benign and malignant thyroid tumors in postmenopausal women.

BMC Clin. Pathol. 13 , 25, (2014)

Estrogen metabolism may be associated with the pathophysiological development of papillary thyroid carcinoma (PTC).To evaluate the differential estrogen metabolism between benign and malignant PTCs, e...

Urinary hydroxyestrogens and breast cancer risk among postmenopausal women: a prospective study.

Cancer Epidemiol. Biomarkers Prev. 14(9) , 2137-42, (2005)

It has been suggested that a low level of the 2-hydroxyestrogen metabolites (2-OHE) and a high level of 16alpha-hydroxyestrone (16alpha-OHE1) are associated with an enhanced risk of breast cancer. We ...

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