kb-NB142-70

Suppliers

Names

[ Name ]:
kb-NB142-70

[Synonym ]:
[1]Benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one, 3,4-dihydro-9-hydroxy-
9-Hydroxy-3,4-dihydro[1]benzothieno[2,3-f][1,4]thiazepin-5(2H)-one
9-hydroxy-3,4-dihydro-2H-[1]benzothiolo[2,3-f][1,4]thiazepin-5-one
kb NB 142-70

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
601.9±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₁H₉NO₂S₂

[ Molecular Weight ]:
251.325

[ Flash Point ]:
317.8±31.5 °C

[ Exact Mass ]:
251.007462

[ PSA ]:
106.36000

[ LogP ]:
2.39

[ Appearance of Characters ]:
white solid

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.746

[ Storage condition ]:
-20℃

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Methyl 5-(benzyloxy)-3-chlorobenzo[b]thiophene-2-carboxylate
3-chloro-5-phenylmethoxy-1-benzothiophene-2-carbonyl chloride
3-benzyloxycinnamic acid
trans-3-Hydroxycinnamic acid

DownStream

Articles

Targeting vascular endothelial growth factor receptor 2 and protein kinase D1 related pathways by a multiple kinase inhibitor in angiogenesis and inflammation related processes in vitro.

PLoS ONE 10(4) , e0124234, (2015)

Emerging evidence suggests that the vascular endothelial growth factor receptor 2 (VEGFR2) and protein kinase D1 (PKD1) signaling axis plays a critical role in normal and pathological angiogenesis and...

PKD1 is downregulated in non-small cell lung cancer and mediates the feedback inhibition of mTORC1-S6K1 axis in response to phorbol ester.

Int. J. Biochem. Cell Biol. 60 , 34-42, (2015)

Protein kinase D1 (PKD1) is increasingly implicated in multiple biological and molecular events that regulate the proliferation or invasiveness in several cancers. However, little is known about the e...

Positive cross talk between protein kinase D and β-catenin in intestinal epithelial cells: impact on β-catenin nuclear localization and phosphorylation at Ser552.

Am. J. Physiol. Cell Physiol. 310 , C542-57, (2016)

Given the fundamental role of β-catenin signaling in intestinal epithelial cell proliferation and the growth-promoting function of protein kinase D1 (PKD1) in these cells, we hypothesized that PKDs me...

KB-0742 HCl
KB-5492 free base
KB-0742 dihydrochloride
KB SRC 4
kb-NB77-78
KB-5246
tert-Butyl 3-(((pyridin-3-ylmethyl)amino)methyl)piperidine-1-carboxylate
(4-(1H-pyrrol-1-yl)phenyl)(4-(((4-chlorobenzyl)oxy)methyl)piperidin-1-yl)methanone
Benzo[d][1,3]dioxol-5-yl(4-(((4-chlorobenzyl)oxy)methyl)piperidin-1-yl)methanone
(2-Bromophenyl)(4-(((4-chlorobenzyl)oxy)methyl)piperidin-1-yl)methanone
(3-Bromophenyl)(4-(((4-chlorobenzyl)oxy)methyl)piperidin-1-yl)methanone
tert-Butyl 3-((((2-bromopyridin-4-yl)methyl)amino)methyl)piperidine-1-carboxylate
tert-Butyl 3-((((2-chloropyrimidin-4-yl)methyl)amino)methyl)piperidine-1-carboxylate
(4-(((4-Chlorobenzyl)oxy)methyl)piperidin-1-yl)(4-(trifluoromethyl)phenyl)methanone
N-(2-(1-benzylpiperidin-3-yl)ethyl)cyclopropanamine
(E)-1-(4-(((4-chlorobenzyl)oxy)methyl)piperidin-1-yl)-3-phenylprop-2-en-1-one

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