Biperidene hydrochloride
Suppliers
Names
[ CAS No. ]:
1235-82-1
[ Name ]:
Biperidene hydrochloride
[Synonym ]:
1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol,hydrochloride
1-Piperidinepropanol, α-bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-, hydrochloride (1:1)
1-(Bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piperidin-1-yl)propan-1-ol hydrochloride (1:1)
1-bicyclo[2.2.1]hept-5-en-2-yl-1-phenyl-3-piperidin-1-ylpropan-1-ol hydrochloride
a-5-Norbornen-2-yl-a-phenyl-1-piperidinepropanol Hydrochloride
EINECS 214-976-2
1-(Bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(1-piperidinyl)-1-propanol hydrochloride (1:1)
1-Bicyclo[2.2.1]hept-5-en-2-yl-1-phenyl-3-piperidin-1-ylpropan-1-olhydrochlorid
Biperiden Hydrochloride
1-Bicycloheptenyl-1-phenyl-3-piperidinopropanol Hydrochloride
a-Bicyclo[2.2.1]hept-5-en-2-yl-a-phenyl-1-piperidinepropanol hydrochloride
1-piperidinepropanol, α-bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-, hydrochloride
1-bicyclo[2.2.1]hept-5-én-2-yl-1-phényl-3-pipéridin-1-ylpropan-1-ol chlorhydrate
Biperidene hydrochloride
biperidine hydrochloride
Biperiden (Hydrochloride)
Chemical & Physical Properties
[ Boiling Point ]:
462.1ºC at 760 mmHg
[ Melting Point ]:
101ºC
[ Molecular Formula ]:
C21H30ClNO
[ Molecular Weight ]:
347.922
[ Flash Point ]:
224.5ºC
[ Exact Mass ]:
347.201599
[ PSA ]:
23.47000
[ LogP ]:
4.70230
[ Vapour Pressure ]:
2.45E-09mmHg at 25°C
[ Water Solubility ]:
DMSO: >20mg/mL
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TN3706000
- CHEMICAL NAME :
- 1-Piperidinepropanol, alpha-5-norbornen-2-yl-alpha-phenyl-, hydrochloride
- CAS REGISTRY NUMBER :
- 1235-82-1
- LAST UPDATED :
- 199509
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C21-H29-N-O.Cl-H
- MOLECULAR WEIGHT :
- 347.97
- WISWESSER LINE NOTATION :
- L55 A CUTJ FXQR&2- AT6NTJ &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 750 mg/kg
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Behavioral - fluid intake Behavioral - muscle weakness
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,379,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 530 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 1,74,1967
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 56 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,192,1989
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 340 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - muscle weakness
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,379,1960 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 19950 mg/kg/5W-C
- TOXIC EFFECTS :
- Related to Chronic Data - death
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,379,1960
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 75600 mg/kg/36W-C
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,379,1960
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 36400 mg/kg/26W-C
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,379,1960
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H319
[ Precautionary Statements ]:
P301 + P312 + P330-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
R22
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
TN3706000
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