3',5'-Difluoroacetophenone

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Names

[ CAS No. ]:
123577-99-1

[ Name ]:
3',5'-Difluoroacetophenone

[Synonym ]:
1-(3,5-Difluorophenyl)-1-ethanone
1-(3,5-Difluorophenyl)ethan-1-one
1-Acetyl-3,5-difluorobenzene
3‘,5‘-Difluoroacetophenone
Ethanone, 1-(3,5-difluorophenyl)-
1-(3,5-Difluorophenyl)ethanone
3′,5′-Difluoroacetophenone
FR CF EV1
3,5-Difluoroacetophenone
3',5'-Difluoroacetophenone
MFCD00042489

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
190.7±20.0 °C at 760 mmHg

[ Melting Point ]:
34-38 °C(lit.)

[ Molecular Formula ]:
C8H6F2O

[ Molecular Weight ]:
156.129

[ Flash Point ]:
70.3±15.9 °C

[ Exact Mass ]:
156.038666

[ PSA ]:
17.07000

[ LogP ]:
1.91

[ Vapour Pressure ]:
0.5±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.473

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2914700090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1-Bromo-3,5-difluorobenzene
  • Acetyl chloride
  • Ethanoic anhydride

DownStream

  • 2-Bromoacetophenone
  • 2-Bromo-1-(3,5-difluorophenyl)ethanone
  • 1-(3,5-Difluorophenyl)ethanol

Customs

[ HS Code ]: 2914700090

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

Articles

Electronically tuned 1,3,5-triarylpyrazolines as Cu(I)-selective fluorescent probes.

Org. Biomol. Chem. 8(2) , 363-70, (2010)

We have prepared and characterized a Cu(i)-responsive fluorescent probe, constructed using a large tetradentate, 16-membered thiazacrown ligand ([16]aneNS(3)) and 1,3,5-triaryl-substituted pyrazoline ...

Synthesis of fluorinated 1-(3-morpholin-4-yl-phenyl)-ethylamines.

Bioorg. Med. Chem. Lett. 13(10) , 1725-8, (2003)

The synthesis of four (+/-)-fluorinated 1-(3-morpholin-4-yl-phenyl)-ethylamines and an enantioselective approach to these amines through reductive amination are described.

(E)-1-(3, 5-Difluorophenyl)-3-(2, 4-dimethoxyphenyl) prop-2-en-1-one. Huang T, et al.

Acta Crystallogr. Sect. E Struct. Rep. Online 66(10) , o2518-o2518, (2010)


More Articles

Related Compounds

  • 3',5'-Difluoroacetophenone oxime
  • 2-bromo-3',5'-difluoroacetophenone
  • 4'-amino-3',5'-difluoroacetophenone
  • 3',5'-di-O-(tert-butyldiphenyl)silyl-α,α-difluorothymidine
  • 3',5'-bis-O-(tert-butyldiphenylsilyl)-5-bromomethyl-2'-deoxyuridine
  • 3',5'-dichloro-2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-carbaldehyde