Levomepromazine hydrochloride

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Names

[ Name ]:
Levomepromazine hydrochloride

[Synonym ]:
methotrimeprazine hydrochloride
Levopromazine hydrochloride
Einecs 214-978-3
(R)-3-(2-Methoxy-10H-phenothiazin-10-yl)-N,N,2-trimethylpropylamine hydrochloride
Levomepromazinium chloride
7044 Rp hydrochloride
LevomepromazineHCl

Chemical & Physical Properties

[ Boiling Point ]:
468ºC at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₅ClN₂OS

[ Molecular Weight ]:
364.93300

[ Flash Point ]:
236.8ºC

[ Exact Mass ]:
364.13800

[ PSA ]:
41.01000

[ LogP ]:
5.36260

[ Vapour Pressure ]:
6.22E-09mmHg at 25°C

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SO6150000

CHEMICAL NAME :: Phenothiazine, 10-(3-(dimethylamino)-2-methylpropyl)-2-methoxy-, hydrochloride

CAS REGISTRY NUMBER :: 1236-99-3

LAST UPDATED :: 199707

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C19-H24-N2-O-S.Cl-H

MOLECULAR WEIGHT :: 364.97

WISWESSER LINE NOTATION :: T C666 BN ISJ B1Y1&1N1&1 EO1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 380 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 15,455,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 135 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 160,1852,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 360 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 155,1029,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Behavioral - sleep

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 19,87,1962

Related Compounds

(Rac)-Levomepromazine-d3 hydrochloride
(±)-Levomepromazine-d6 hydrochloride
carnitine hydrochloride
Losoxantrone hydrochloride [USAN]
Triprolidine hydrochloride
Tyrocidine, hydrochloride
3-(But-3-en-2-yl)-1-(2-cyclobutylethyl)thiourea
3-(But-3-en-2-yl)-1-(5-hydroxypentan-2-yl)thiourea
3-(But-3-en-2-yl)-1-[(4-fluorophenyl)methyl]thiourea
3-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]piperidine
tert-butyl N-{2-[1-(1-aminoethyl)cyclopropyl]-5-(trifluoromethyl)phenyl}carbamate
3-{[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)but-2-ynamido]methyl}oxolane-2-carboxylic acid
2-(4-Methyloxan-4-yl)azetidine
3-[2-(piperidin-3-yloxy)ethyl]-1H-indole
3-[(3S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pentanamido]-2-methylpropanoic acid
4-{[3-(dimethylamino)cyclobutyl]carbamoyl}-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoic acid

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