Dolastatin 15

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Names

[ Name ]:
Dolastatin 15

[Synonym ]:
(5S)-1-[(2S)-O-(N,N-DIMETHYL-VAL-VAL-N-ME-VAL-PRO-PRO)-2-HYDROXYISOVALERYL]-2-OXO-4-METHOXY-5-BENZYL-3-PYRROLINE
(5S)-1-[(2S)-O-(N,N-Val-Val-N-Me-Val-Pro-Pro)-2-hydroxyisovaleryl]-2-oxo-4-methoxy-5-benzyl-3-pyrroline
(5S)-1-{(2S)-O-[(N,N-dimethyl-L-valyl)-L-valyl-(N-methyl-L-valyl)-L-prolyl-L-prolyl]-2-hydroxy-isovaleryl}-2-oxo-4-methoxy-5-benzyl-3-pyrroline
(5S)-1-[N,N-Dimethyl-L-Val-L-Val-N-methyl-L-Val-L-Pro-L-Pro-L-Hyiv-]-5-benzyl-4-methoxy-1H-pyrrol-2(5H)-one
L-Proline,1-(1-(N-(N-(N,N-dimethyl-L-valyl)-L-valyl)-N-methyl-L-valyl)-L-propyl)-,1-((2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1H-pyrrol-1-yl)carbonyl)-2-methylpropyl ester,(S-(R*,R*))
dolastatin-15
L-Proline,1-(1-(N-(N-(N,N-dimethyl-L-valyl)-L-valyl)-N-methyl-L-valyl)-L-prolyl)-,1-((2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1H-pyrrol-1-yl)carbonyl)-2-methylpropyl ester,(S-(R*,R*))

Chemical & Physical Properties

[ Density]:
1.2g/cm3

[ Boiling Point ]:
943.2ºC at 760mmHg

[ Molecular Formula ]:
C₄₅H₆₈N₆O₉

[ Molecular Weight ]:
837.05600

[ Flash Point ]:
524.2ºC

[ Exact Mass ]:
836.50500

[ PSA ]:
166.18000

[ LogP ]:
3.46120

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.572

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

End-binding proteins sensitize microtubules to the action of microtubule-targeting agents.

Proc. Natl. Acad. Sci. U. S. A. 110(22) , 8900-5, (2013)

Microtubule-targeting agents (MTAs) are widely used for treatment of cancer and other diseases, and a detailed understanding of the mechanism of their action is important for the development of improv...

The bcl-2 and p53 oncoproteins can be modulated by bryostatin 1 and dolastatins in human diffuse large cell lymphoma.

Anticancer Drugs 6(3) , 392-7, (1995)

The effects of dolastatin 10 (Dol10) and dolastatin 15 (Dol15) alone, and after treatment with bryostatin 1 (Bryo1), on human diffuse large cell lymphoma cell line (WSU-DLCL2) were studied. At a conce...

Effects of dolastatins on human B-lymphocytic leukemia cell lines.

Leuk. Res. 17(4) , 333-9, (1993)

Dolastatins are naturally occurring peptides isolated from marine animals and are known to be potent anti-neoplastic agents. Here, the three compounds dolastatin 10 (Dola 10), dolastatin 15 (Dola 15) ...

dolastatin 1
dolastatin 14
(8S,14S,17S,20S,25S)-17-benzyl-2-butan-2-yl-28-ethyl-7,13,16,20,22,22,24,25,29-nonamethyl-8-(2-methylpropyl)-14-propan-2-yl-1-oxa-4,7,10,13,16,19,24,27-octazacyclotriacontane-3,6,9,12,15,18,21,23,26,30-decone
bis(15-methyl-3,6,9,12-tetraoxahexadecyl) hydrogen phosphate
triacontan-15-ol
syn-15,18-Dimethoxy<3>(2,6)-p-benzoquinono<3>metacyclophane
2-(3-Pyridinylmethyl)benzoic acid
Ac-Phg(4-OH)-OEt
3-(2-Carbamoylphenyl)propanoic acid
2-Methyl-5-(trifluoromethyl)imidazo[1,2-a]pyridin-3-amine
(2R)-2-(3,5-dimethylphenyl)propanoic acid
(2R,3R)-4-[(E)-3-[(1R)-1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy]-3-oxoprop-1-enyl]-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-3-carboxylic acid
2-(2-Aminoethyl)-5-methyl-1,3-oxazole-4-carboxylic acid hydrochloride (1:1)
Benzyl (4-(hydroxymethyl)bicyclo[2.2.1]heptan-1-yl)carbamate
rac-(1R,2R)-2-(1H-1,2,4-triazol-3-yl)cyclopropane-1-carboxylic acid
(1R,2S)-2-(1H-1,2,4-Triazol-5-yl)cyclopropane-1-carboxylic acid

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