(R)-(+)-HA-966

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Names

[ CAS No. ]:
123931-04-4

[ Name ]:
(R)-(+)-HA-966

[Synonym ]:
MFCD00078583
R(+)-3-Amino-1-hydroxy-2-pyrrolidinone

Chemical & Physical Properties

[ Density]:
1.436g/cm3

[ Boiling Point ]:
258.6ºC at 760mmHg

[ Molecular Formula ]:
C4H8N2O2

[ Molecular Weight ]:
116.11900

[ Flash Point ]:
110.2ºC

[ Exact Mass ]:
116.05900

[ PSA ]:
66.56000

[ Vapour Pressure ]:
0.002mmHg at 25°C

[ Index of Refraction ]:
1.59

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative.

Proc. Natl. Acad. Sci. U. S. A. 87 , 347, (1990)

The antagonist effect of (+/-)-3-amino-1-hydroxypyrrolid-2-one (HA-966) at the N-methyl-D-aspartate (NMDA) receptor occurs through a selective interaction with the glycine modulatory site within the r...

The discriminative stimulus properties of (+)-HA-966, an antagonist at the glycine/N-methyl-D-aspartate receptor.

Eur. J. Pharmacol. 186 , 129, (1990)

Using a two-lever operant drug discrimination paradigm, rats have been trained to discriminate between the administration of saline and R-(+)-HA-966 (R-(+)-3-amino-1-hydroxypyrrolid-2-one, 30 mg/kg i....

Stereoselectivity for the (R)-enantiomer of HA-966 (1-hydroxy-3-aminopyrrolidone-2) at the glycine site of the N-methyl-D-aspartate receptor complex.

J. Neurochem. 55 , 1346, (1990)

HA-966 (1-hydroxy-3-aminopyrrolidone-2) is an antagonist at the glycine allosteric site of the N-methyl-D-aspartate receptor ionophore complex. Unlike presently known glycine antagonists, HA-966 is ch...


More Articles

Related Compounds

  • R(+)-3-(3-HYDROXYPHENYL)-N-PROPYLPIPERIDINE HYDROCHLORIDE
  • (R)-(+)-2,2',6,6'-TETRAMETHOXY-4,4'-BIS(DIPHENYLPHOSPHINO)-3,3'-BIPYRIDINE(1,5-CYCLOOCTADIENE)RHODIUM(I) TETRAFLUOROBORATE
  • (R)-(+)-6-chloro-7-hydroxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline
  • (R)-(+)-N-[[1-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-4-piperidinyl]methyl]-2-benzothiazolamine
  • R(+)-7-HYDROXY-2-DIPROPYLAMINO TETRALIN&
  • [(R)-(+)-2,2′-Bis(di-p-tolylphosphino)-1,1′-binaphthyl]palladium(II) chloride
  • Methyl 5-(2-aminoethyl)-2-methoxybenzoate hydrochloride
  • Methyl 2-(2,5-dimethylmorpholin-4-yl)-1,3-thiazole-4-carboxylate
  • tert-Butyl (2-bromo-5-(hydroxymethyl)benzyl)carbamate
  • 3-Ethoxy-2-(1,2,3,6-tetrahydropyridin-4-yl)pyridine;hydrochloride
  • Ethyl 1-(5-ethylpyrimidin-2-yl)piperidine-4-carboxylate
  • Methyl 2-(2-hydroxy-5-iodophenyl)acetate
  • 3-({2-[4-(1-Methylpiperidin-4-yl)piperazin-1-yl]-2-oxoethoxy}methyl)morpholine
  • N-(2,4-dimethyl-6-nitro-phenyl)-N-propyl-acetamide
  • 5-(6-Methyl-pyridin-3-ylamino)-pyridine-2-carboxylic acid
  • 2-(Cyclopropyl(hydroxy)methyl)benzonitrile
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