(R)-(+)-HA-966

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Names

[ CAS No. ]:
123931-04-4

[ Name ]:
(R)-(+)-HA-966

[Synonym ]:
MFCD00078583
R(+)-3-Amino-1-hydroxy-2-pyrrolidinone

Chemical & Physical Properties

[ Density]:
1.436g/cm3

[ Boiling Point ]:
258.6ºC at 760mmHg

[ Molecular Formula ]:
C4H8N2O2

[ Molecular Weight ]:
116.11900

[ Flash Point ]:
110.2ºC

[ Exact Mass ]:
116.05900

[ PSA ]:
66.56000

[ Vapour Pressure ]:
0.002mmHg at 25°C

[ Index of Refraction ]:
1.59

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative.

Proc. Natl. Acad. Sci. U. S. A. 87 , 347, (1990)

The antagonist effect of (+/-)-3-amino-1-hydroxypyrrolid-2-one (HA-966) at the N-methyl-D-aspartate (NMDA) receptor occurs through a selective interaction with the glycine modulatory site within the r...

The discriminative stimulus properties of (+)-HA-966, an antagonist at the glycine/N-methyl-D-aspartate receptor.

Eur. J. Pharmacol. 186 , 129, (1990)

Using a two-lever operant drug discrimination paradigm, rats have been trained to discriminate between the administration of saline and R-(+)-HA-966 (R-(+)-3-amino-1-hydroxypyrrolid-2-one, 30 mg/kg i....

Stereoselectivity for the (R)-enantiomer of HA-966 (1-hydroxy-3-aminopyrrolidone-2) at the glycine site of the N-methyl-D-aspartate receptor complex.

J. Neurochem. 55 , 1346, (1990)

HA-966 (1-hydroxy-3-aminopyrrolidone-2) is an antagonist at the glycine allosteric site of the N-methyl-D-aspartate receptor ionophore complex. Unlike presently known glycine antagonists, HA-966 is ch...


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