Cevane-3,4,12,14,16,17,20-heptol,4,9-epoxy-, (3a,4a,16b)-

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Names

[ CAS No. ]:
124-98-1

[ Name ]:
Cevane-3,4,12,14,16,17,20-heptol,4,9-epoxy-, (3a,4a,16b)-

[Synonym ]:
SABADININE
Cevane-3,4,12,14,16,17,20-heptol,4,9-epoxy-, (3a,4a,16b)-

Chemical & Physical Properties

[ Density]:
1.5g/cm3

[ Boiling Point ]:
693.5ºC at 760mmHg

[ Molecular Formula ]:
C27H43NO8

[ Molecular Weight ]:
509.63200

[ Flash Point ]:
373.2ºC

[ Exact Mass ]:
509.29900

[ PSA ]:
154.08000

[ Vapour Pressure ]:
3.01E-22mmHg at 25°C

[ Index of Refraction ]:
1.684

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
FL4550000
CHEMICAL NAME :
Cevane-3-alpha,4-beta,12,14,16-beta,17,20-heptol, 4,9-epoxy-
CAS REGISTRY NUMBER :
124-98-1
LAST UPDATED :
199010
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C27-H43-N-O8
MOLECULAR WEIGHT :
509.71
WISWESSER LINE NOTATION :
T J6 H6 E6 D5665/TC& 3ATU C& ON TX C&OTJ EQ GQ HQ IQ I1 M1 RQ U1 A&Q B&Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
67 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 82,167,1944
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
160 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 113,89,1955

Safety Information

[ RIDADR ]:
UN 1544

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

Synthetic Route

Precursor & DownStream

Precursor

  • VERATRINE
  • Cevagenin
  • Cevane-3,4,12,14,16,17,20-heptol,4,9-epoxy-, (3a,4a,16b)-
  • Ethanol
  • Veratridine

DownStream

  • 2-Ethyl-5-methylpyridine
  • 3-Mepy
  • (3S)-3-Methylpiperidine
  • Cevane-3,4,12,14,16,17,20-heptol,4,9-epoxy-, (3a,4a,16b)-
  • Cevagenin

Related Compounds

  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 2-Chloro-6-(2,3,6-trimethylphenoxy)benzaldehyde
  • 2-(3-(benzo[d][1,3]dioxol-5-yl)-2-oxoimidazolidin-1-yl)-N-(3-(methylthio)phenyl)acetamide