N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]-3,4,5-trimethoxybenzamide
Names
[ CAS No. ]:
124012-42-6
[ Name ]:
N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]-3,4,5-trimethoxybenzamide
[Synonym ]:
Galocitabinum [INN-Latin]
Cytidine,5'-deoxy-5-fluoro-N-(3,4,5-trimethoxybenzoyl)
Galocitabine [INN]
5'-deoxy-5-fluoro-N4-(3,4,5-trimethoxybenzoyl)cytidine
5'-Deoxy-5-fluoro-N-(3,4,5-trimethoxybenzoyl)cytidine
N4-Trimethoxybenzoyl-5'-deoxy-5-fluorocytidine
Galocitabina [INN-Spanish]
galocitabine
Ro-09-1390
Chemical & Physical Properties
[ Molecular Formula ]:
C19H22FN3O8
[ Molecular Weight ]:
439.39200
[ Exact Mass ]:
439.13900
[ PSA ]:
141.37000
[ LogP ]:
0.37260
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- HA3857500
- CHEMICAL NAME :
- Cytidine, 5'-deoxy-5-fluoro-N-(3,4,5-trimethoxybenzoyl)-
- CAS REGISTRY NUMBER :
- 124012-42-6
- LAST UPDATED :
- 199703
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C19-H22-F-N3-O8
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6300 mg/kg/7D-I
- TOXIC EFFECTS :
- Endocrine - changes in thymus weight Blood - changes in bone marrow (not otherwise specified) Blood - changes in leukocyte (WBC) count
- REFERENCE :
- JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 21,29,1996