2,3-DIHYDRO-3,3-DIMETHYL-2-FLUORO-1,2-BENZISOTHIAZOLE 1,1-DIOXIDE

Names

[ CAS No. ]:
124170-23-6

[ Name ]:
2,3-DIHYDRO-3,3-DIMETHYL-2-FLUORO-1,2-BENZISOTHIAZOLE 1,1-DIOXIDE

[Synonym ]:
1,2-Benzisothiazole,2-fluoro-2,3-dihydro-3,3-dimethyl-,1,1-dioxide
2,3-Dihydro-3,3-dimethyl-2-fluoro-1,2-benzisothiazole 1,1-dioxide
N-fluoro-3,3-dimethyl-2,3-dihydro-1,2-benzothiazole-1,1-dioxide
N-Fluoro-2,|A-cumenesultam
N-fluoro-3,3-dimethyl-2,3-dihydro-1,2-benzothiazol-1,1-dioxide
2-fluoro-3,3-dimethyl-2,3-dihydro-1,2-benzisothiazole-1,1-dioxide
N-fluorosultam

Chemical & Physical Properties

[ Density]:
1.41g/cm3

[ Boiling Point ]:
307.6ºC at 760 mmHg

[ Melting Point ]:
115-117ºC

[ Molecular Formula ]:
C9H10FNO2S

[ Molecular Weight ]:
215.24500

[ Flash Point ]:
139.9ºC

[ Exact Mass ]:
215.04200

[ PSA ]:
45.76000

[ LogP ]:
2.82920

[ Vapour Pressure ]:
0.000715mmHg at 25°C

[ Index of Refraction ]:
1.59

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2934991000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2,3-DIHYDRO-3,3-DIMETHYL-1,2-BENZISOTHIAZOLE 1,1-DIOXIDE

DownStream

  • 2,3-DIHYDRO-3,3-DIMETHYL-1,2-BENZISOTHIAZOLE 1,1-DIOXIDE

Customs

[ HS Code ]: 2934991000

[ Summary ]:
2934991000. sultones and sultams. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Integration of lead optimization with crystallography for a membrane-bound ion channel target: discovery of a new class of AMPA receptor positive allosteric modulators.

J. Med. Chem. 54(1) , 78-94, (2011)

A novel series of AMPAR positive modulators is described that were identified by high throughput screening. The molecules of the series have been optimized from a high quality starting point hit to af...

E. Differding et al.

Tetrahedron Lett. 32 , 1779, (1991)

E. Differding, M. Wehrli

Tetrahedron Lett. 32 , 3819, (1991)


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